Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Patent
1997-12-23
1999-08-03
Hobbs, Lisa
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
435440, 435 6, 536 232, 536 243, 5303871, C12N 900, C12N 1500, C12Q 168, C07H 2104
Patent
active
059324619
ABSTRACT:
The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.
REFERENCES:
patent: 5561054 (1996-10-01), Kron et al.
Bausch et al. (1998) Analysis and Overexpression in Escherichia coli of a Staphylococcal Gene Encoding Seryl-tRNA Synthetase. Biochim. Biophys. Acta 1397(2): 169-174.
Kron, et al., "An immunodominant antigen of Brugia malayi is an asparaginyl-tRNA synthetase", FEBS Letters, 374 pp. 122-124 (1995).
Chalker, et al., "Analysis and toxic overexpression in Escherichia coli of a staphylococcal gene encoding isoleucyl-tRNA synthetase", Gene, 141, pp. 103-108 (1994).
Nilsen, et al., "Cloning and characterization of a potentially protective antigen in lymphatic filariasis", Proc Natl. Acad. Sci. USA, 85, pp. 3604-3607 (1988).
Hodgson John Edward
Lawlor Elizabeth Jane
Gimmi Edward R.
Hobbs Lisa
Jackson Arthur E.
King William T.
SmithKline Beecham plc
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