Serum pretreatment in digoxin immunoassay

Details Serum pretreatment in digoxin immunoassay Serum pretreatment in digoxin immunoassay

1987-02-05

1989-01-17

Warden, Robert J.

Chemistry: analytical and immunological testing

Heterocyclic carbon compound

Hetero-o

436177, 436518, 436536, 436815, 436825, G01N 3300, G01N 118, G01N 3353

Patent

active

047988045

ABSTRACT:
A method is disclosed for preparing a sample suspected of containing digoxin for determination of digoxin in the sample during an assay. The method comprises contacting the sample with .beta.-cyclodextrin in an amount and under conditions sufficient to allow a substantial portion of digoxin in the sample to bind to the .beta.-cyclodextrin. The .beta.-cyclodextrin with bound digoxin is separated from at least one other component of the medium. Next, the digoxin is released from the .beta.-cyclodextrin to provide a sample containing digoxin which may be analyzed by any of a number of assay techniques.

REFERENCES:
patent: 4056608 (1977-11-01), Ullman et al.
patent: 4121975 (1978-10-01), Ullman et al.
patent: 4555504 (1985-11-01), Jones
patent: 4654311 (1987-03-01), Khanna et al.
patent: 4698315 (1987-10-01), Farrenkopf et al.
Otta et al., Chem. Abs., 97, 187657n, 1982.

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