Serum marker for measuring liver fibrosis

Chemistry: analytical and immunological testing – Heterocyclic carbon compound – Hetero-o

Reexamination Certificate

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Details

C436S063000, C436S093000, C536S053000

Reexamination Certificate

active

11180867

ABSTRACT:
The invention provides methods and kits to detect liver fibrosis or a change in the gradation of liver fibrosis in mammals. The diagnostic marker is based on the profiling and identification of diagnostic carbohydrates present in a body fluid such as blood serum.

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PCT International Search Report, PCT/EP2004/050018, dated Jul. 2, 2004.
PCT International Preliminary Examination Report, PCT/EP2004/050018, dated Jul. 2, 2004.
Miyamoto et al., “Characteristics of Lectin Staining Patterns Assessed by a Modified Sensitive Thermo-Method in Rat Livers with Heterologous Serum-Induced Fibrosis,” Journal of Veterinary Medical Science, Aug. 1998, pp. 953-960, vol. 60, No. 60.
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Imbert-Bismut F. et al. Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study.Lancet357, 1069-1075 (2001).
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