Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-07-10
1999-10-26
Cunningham, Thomas M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530300, 530350, 530395, 4241851, C07K 700, C07K 14745
Patent
active
059731222
ABSTRACT:
Previously unisolated serum immunoregulatory polypeptides (SIPs) having a molecular weight of approximately 14,000 to 31,000 are provided. The SIPs may be obtained from hemorrhagic serum of mammals and have been shown to activate suppressor T-cells and suppress lymphocyte proliferation and interleukin production. There is a significant homology between SIPs of different mammalian species. The amino acid sequence of an SIP having a molecular weight of about 16,000 is provided. In addition, immunosuppressive polypeptides are identified which have the formula (SEQ ID NO:2):
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Kohler et al., "Continuous cultures of fused cells secreting antibody of predefined specificity," Nature, vol. 256, pp. 495-497, 1975.
Abraham et al., "Effects of hemorrhagic serum on interleukin-2 generation and utilization," Critical Care Medicine, vol. 16, No. 4, pp. 307-311, 1988.
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Abraham et al., "Generation of functionally active suppressor cells by hemorrhage and haemorrhagic serum," Clin. exp. Immunol. (1988) 72, 238-242 .
Abraham Edward
Chang Yi-Han
Cunningham Thomas M.
The Regents of the University of California
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