Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1975-07-21
1977-07-05
Padgett, Benjamin R.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
23230B, 424 15, 424 12, G01N 3300, A61K 3900, G21H 502
Patent
active
040340724
ABSTRACT:
Reagent and method for detecting the presence of hepatitis associated antigen (HAA) in blood serum. The reagent comprises anti-HAA antibodies coupled via an intermediate silane to a plurality of siliceous particles having a surface area of at least about 1 m.sup.2 /g and, if the particles are porous, an average pore diameter of at least about 1000 A. The test method comprises the steps of incubating a serum sample with the reagent to complex any HAA in the samplewith the antibodies of the reagent, incubating the reaction product with a solution of radio labelled anti-HAA antibodies to complex the labelled antibodies with any HAA that may be complexed to the reagent, separating the incubation products from the solution of labelled antibodies, and counting the radioactivity of either the separated products or the remaining solution to determine whether HAA was in the sample.
REFERENCES:
patent: 3555143 (1971-01-01), Axen et al.
patent: 3652761 (1972-03-01), Weetall
patent: 3867517 (1975-02-01), Ling
Weetall, Biochem. Journal, vol. 117, 1970, pp. 257-261.
Bodley et al., steroids, vol. 21, No. 1, Jan. 1973, pp. 1-16.
Leonard et al., Radioimmunoassay and Related Procedures in Medicine, vol. II, Viena, 1974, pp. 367-375.
Mjos Shirley A.
Piasio Roger N.
Corning Glass Works
Giblin James A.
Janes Jr. Clinton S.
Nucker Christine M.
Padgett Benjamin R.
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