Serum-free medium containing retinoic acid useful for cultivatin

Details Serum-free medium containing retinoic acid useful for cultivatin Serum-free medium containing retinoic acid useful for cultivatin

1988-08-11

1992-10-13

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 7021, 43524031, 53038815, 530865, 935 99, 935100, C12N 500, C12N 1500, A61K 3514, C12P 2102

Patent

active

051550369

ABSTRACT:
A serum-free medium for cultivating a human monoclonal antibody-producing human/human hybridoma, said medium comprising a serum-free complete medium and at least 10.sup.-12 M but not more than 10.sup.-6 M of retinoic acid or its salt.

REFERENCES:
patent: 4205126 (1980-05-01), Cartaya
Muakami et al. Human-Human Hybridomas Secreting Antibodies Specific to Human Lung Carcinoma; In Vitro Cellular & Developmental Biology v. 21, No. 10 pp. 593-596 1985.
Rodrigues et al. Exp. Cell Research 156 (1985) 22-30.
Barnes & Sato Analytical Biochemistry 102 255-270 (1980).
Journal of Immunological Methods, vol. 57, 1983, pp. 121-136, "Automated Production of Monoclonal Antibodies in a Cytostat" by S. Fazekas de St. Groth.
Chemical Abstracts, vol. 97, 1982, p. 365, Abstract No. 159112n, "Clonal Growth of Normal Adult Human Bronchial Epithelial Cells in a Serum-Free Medium".
Biological Abstracts, vol. 79, 1985, Abstract No. 22483, "Immunological aspects of retinoids in humans: 2. Retinoic acid enhances induction of hemolytic plaque-forming cells".
Chemical Abstracts, vol. 103, 1985, p. 575, abstract no. 121561n, "Potentiation of Mitogen-Induced human T-lymphocyte activation by retinoic acid".
"Monoclonal Antibodies: Production and Application (Advances in Biotechnological Processes, vol. II)", Mizrahi.
"Enhancing Effects of Retinoic Acid on Monoclonal Antibody Production of Human-Human Hybridomas", Cellular Immonology I33, 498-505 (1991) Aotsuka and Naito.

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