Serum-free, cell-free vaccine effective against pneumonic pasteu

Details Serum-free, cell-free vaccine effective against pneumonic pasteu Serum-free, cell-free vaccine effective against pneumonic pasteu

1990-01-12

1992-11-24

Marx, Irene

Drug, bio-affecting and body treating compositions

Lymphokine

424 92, 435 713, 4352521, A61K 3900, A61K 3902, C12P 2100, C12N 120

Patent

active

051659247

ABSTRACT:
A serum-free vaccine effective against pneumonic pasteurellosis in cattle comprising a non-toxic leukotoxin specific for ruminant leukocytes is disclosed. The leukotoxin is prepared in a serum-free medium from a culture of Pasteurella haemolytica. The produced leukotoxin is harvested from the culture medium upon detecting a certain stage during the logarithmic phase of the cell growth to obtain the optimum concentration of produced cytotoxin in the serum-free medium. Cattle may be treated with the vaccine to develop anti-leukotoxic immunity to pneumonic pasterellosis.

REFERENCES:
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patent: 4346074 (1982-08-01), Gilmour et al.
patent: 4957739 (1990-09-01), Berget et al.
Baluyut et al., Am. J. Vet. Res., vol. 42, pp. 1920-1926, 1981.
Bergey's Manual of Systematic Bacteriology, Krieg et al., Ed., Williams and Wilkins, 1984, p. 556.
Chang et al., Am. J. Vet. Res., vol. 47, pp. 67-74, 1986.
Shewen et al., Am. J. Vet. Res., vol. 44, pp. 715-719, 1983.
Lo et al., Infect. Immun., pp. 667-671, vol. 50, 1985.
Simpson et al., Infect. Immun., vol. 56, pp. 1162-1166, 1988.
Scanlan et al., Am. J. Vet. Res. vol. 43, pp. 1329-1333, 1982.
Shewen et al., North American Symposium on Bovine Respiratory Disease, Amarillo, Texas, Dec., 1983, Abstract.

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