Sertraline polymorph

Details Sertraline polymorph Sertraline polymorph

1996-05-17

1998-03-31

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C21142

Patent

active

057340838

ABSTRACT:
A novel polymorph of sertraline hydrochloride, i.e. (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenam ine hydrochloride, is disclosed, having improved water solubility along with acceptable stability. It is characterized by a unique x-ray diffraction pattern and unit cell structure, as well as IR and NMR spectral characteristics.

REFERENCES:
patent: 4536518 (1985-08-01), Welch, Jr. et al.
patent: 5248699 (1993-09-01), Sysko et al.

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