Sertoli cells as neurorecovery inducing cells for Parkinson's di

Details Sertoli cells as neurorecovery inducing cells for Parkinson's di Sertoli cells as neurorecovery inducing cells for Parkinson's di

1995-03-13

1997-12-30

Ziska, Suzanne E.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

424 937, 424562, 424558, A01N 6300, A61K 3552, A61K 3822

Patent

active

057027005

ABSTRACT:
A method of generating in situ trophic factor production by transplanting Sertoli cells into the central nervous system of a mammal, the cells creating trophic factors in situ.

REFERENCES:
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Isacson et al., "Graft-induced behavioral recovery in an animal model of Huntington's disease" Proc. Natl. Acad. Sci., 83:2728-2732 (1986).
Lindvall et al., "Transplantation in Parkinson's disease: two cases of adrenal medullary grafts to the putamen" Ann. Neurol. 22:457-468 (1987).
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Pakzaban et al., "Increased proportion of Ache-rich zones and improved morphological integration in host striatum of fetal . . . " Exp. Brain Res., 97:13-22 (1993).
Sanberg et al. "Transplantation into central nervous system" in Cell Transplantation for Huntington's Disease, R.G. Landes Co., Boca Raton, FL, Chap. 4, pp. 19-21 (1994).
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Wictorin et al., "Reformation of long axon pathways in adult rat CNS by human forebrain neuroblasts" Nature, 347:556-558 (1990).
Koutouzies et al., "Cell Transplantation for Central Nervous System Disorders" Critical Reviews in Neurobiology, 8(3):125-162 (1994).

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