Serpulina hyodysenteriae vaccine comprising a hygene mutant

Details Serpulina hyodysenteriae vaccine comprising a hygene mutant Serpulina hyodysenteriae vaccine comprising a hygene mutant

1997-10-15

1999-03-16

Housel, James C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424 92, 424 16, 435 6, 435 693, A61K 3900, A61K 39002

Patent

active

058826556

ABSTRACT:
According to the present invention a vaccine can be prepared containing a mutant Serpulina hyodysenteriae which is defective in its production of biologically active hemolysin. The mutation by which Serpulina hyodysenteriae is made defective in its production of hemolytically active hemolysin is established by means of genetical engineering techniques. Such mutations comprise e.g. deletion of part or the entire gene coding for hemolysin and/or nucleotide sequences controling the production of hemolysin, or insertion of an extra nucleotide or polynucleotide into the gene encoding hemolysin and/or the nucleotide sequences controling the production of hemolysin, or a combination of said deletion and insertion. These vaccines are useful in the prevention of Serpulina infections in susceptible animals such as swine.

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