Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-06-07
1997-12-23
Elliott, George G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
4352402, 4353201, 435 914, 435 691, C12N 1585, C12N 1563, C07H 2104, C12P 1934
Patent
active
057009244
ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode a novel serpin (CAPE) expressed in human hypothalamus. The present invention also provides for antisense molecules to the nucleotide sequences which encode CAPE, expression vectors for the production of purified CAPE, antibodies capable for binding specifically to CAPE, hybridization probes or oligonucleotides for the detection of CAPE-encoding nucleotide sequences, genetically engineered host cells for the expression of Cape, a pharmaceutical composition containing biologically active CAPE, a diagnostic test based on CAPE-encoding nucleic acid molecules, and treatment methods comprising administration of biologically active CAPE.
REFERENCES:
San, H. et al., Safety and Short Term Toxicity of a Novel and Cationic Formulation for Human Gene Therapy, Human Gene Therapy, 781-788, Dec. 1993.
Christoffersen, R. et al., Ribozymes as Human Therapeutic Agents, Journal of Medicinal Chemistry, 2023-2037, Nov. 1994.
Stull, R. et al., Antigene, Ribozyme, and Aptomer Nucleic Acid Drugs: Progress and Prospects, Pharmaceuticals Research, 1995.
Ngo et al., Computational complexity, protein structure prediction, and the Levinthal Paradox, The Protein Folding Problem and Tertiary Structure Prediction, pp. 433-440, 1994.
Loebermann et al., "Human .alpha..sub.1 --Proteinase Inhibitor, Crystal Structure Analysis of Two Crystal Modifications, Molecular Model and Preliminary Analysis of the Implications for Function," J. Mol. Biol. 177:531-556 (1984).
Bruch et al., "Plasma Serine Proteinase Inhibitors (Serpins) Exhibit Major Conformational Changes and a Large Increase in Conformational Stability upon Cleavage at Their Reactive Sites," J. Biol. Chem. 263(32):16626-16630 (Nov. 15, 1988).
Carrell et al., "Serpins: mobile conformation in a family of proteinase inhibitors," Curr. Opin. Struct. Biol. 2(3):438-446 (Jun. 1992).
Mottonen et al., "Structural basis of latency in plasminogen activator inhibitor-1," Nature 355(6357):270-273 (Abstract only) (Jan. 16, 1992).
Pemberton et al., "Hormone binding globulins undergo serpin conformational change in inflammation," Nature 336:257-258 (Nov. 17, 1988).
Carrell et al., ".alpha..sub.1 --Antitrypsin and the serpins: variation and countervariation," TIBS 10:20-24 (Jan. 1985).
Carrell et al., "The Serpins: Evolution and Adaptation in a Family of Protease Inhibitors," Cold Spring Harbor Symp. Quant. Biol. 52:527-535 (1987).
Huber et al., "Implications of the Three-Dimensional Structure of .alpha..sub.1 --Antitrypsin for Structure and Function of Serpins," Biochemistry 28(23):8951-8966 (Nov. 14, 1989).
Remold-O'Donnell, E., "The ovalbumin family of serpin proteins," FEBS 315(2):105-108 (Abstract only) (Jan. 4, 1993).
Morris, J.F., "New anatomical insights into the inputs and outputs from hypothalamic magnocellular neurons," Ann NY Acad. Sci. 689:16-33 (Abstract only) (Jul. 22, 1993).
Renaud et al., "Synapic and neurotransmitter regulation of activity in mammalian hypothalamic magnocellular neurosecretory cells," Prog. Brain Res. 92:227-288 (Abstract only) (1992).
Erlander et al., "Molecular approach to hypothalamic rhythms: isolation of novel indoleamine receptor genes," J. Biol. Rhythms 8 Suppl, pp. 25-31 (Abstract only) (1993).
Braak et al., "Anatomy of the human hypothalamus (chiasmatic and tuberal region)," Prog. Brain Res. 93: 3-14, discussion pp. 14-16 (Abstract only) (1992).
Swaab et al., "Functional neuroanatomy and neuropathology of the human hypothalamus," Anat. Embryol. 187(4):317-330 (Abstract only) (Apr. 1993).
GenBank Sequence Database (Accession No. 271930), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Osterwalder et al., Neuroserpin, an axonally secreted serine protease inhibitor, The Embo Journal, 15(12):2944-2953 (1996).
Braxton Scott Michael
Diep Dinh
Stuart Susan G.
Billings Lucy J.
Elliott George G.
Incyte Pharmaceuticals Inc.
Luther Barbara J.
Wang Andrew
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