Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2008-01-15
2008-01-15
Canella, Karen A. (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
Reexamination Certificate
active
10856109
ABSTRACT:
Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (SixTransmembraneEpithelialAntigen of theProstate). Four particular human STEAP's are described and characterized herein. The human STEAP's exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
REFERENCES:
patent: 6329503 (2001-12-01), Afar et al.
patent: 2002/0022248 (2002-02-01), Xu et al.
patent: 2002/0146692 (2002-10-01), Yamazaki et al.
patent: 2002/0192763 (2002-12-01), Xu et al.
patent: 2003/0060612 (2003-03-01), Goddard et al.
patent: 2003/0064397 (2003-04-01), Spancake et al.
patent: 2003/0100540 (2003-05-01), Zhang et al.
patent: 0 834 563 (1998-04-01), None
patent: 0834563 (1998-04-01), None
patent: 1308459 (2003-05-01), None
patent: 11164691 (1999-06-01), None
patent: 11164691 (1999-06-01), None
patent: WO 94/09150 (1994-04-01), None
patent: WO 95/14772 (1995-06-01), None
patent: WO9514772 (1995-06-01), None
patent: WO9514772 (1995-06-01), None
patent: WO 98/18489 (1998-05-01), None
patent: WO 98/37093 (1998-08-01), None
patent: WO 98/37418 (1998-08-01), None
patent: WO 98/53071 (1998-11-01), None
patent: WO9853071 (1998-11-01), None
patent: WO9853071 (1998-11-01), None
patent: WO 99/06548 (1999-02-01), None
patent: WO 99/06550 (1999-02-01), None
patent: WO 99/61469 (1999-02-01), None
patent: WO9906548 (1999-02-01), None
patent: WO9906548 (1999-02-01), None
patent: WO9906550 (1999-02-01), None
patent: WO9906550 (1999-02-01), None
patent: WO 99/62941 (1999-12-01), None
patent: WO9962941 (1999-12-01), None
patent: WO9962941 (1999-12-01), None
patent: WO 00/04149 (2000-01-01), None
patent: WO0004149 (2000-01-01), None
patent: WO0004149 (2000-01-01), None
patent: WO0004149 (2000-01-01), None
patent: WO 00/35937 (2000-02-01), None
patent: WO 00/35937 (2000-06-01), None
patent: WO0035937 (2000-06-01), None
patent: WO 00/77021 (2000-12-01), None
patent: WO0077021 (2000-12-01), None
patent: WO0077021 (2000-12-01), None
patent: WO 01/12662 (2001-02-01), None
patent: WO0112662 (2001-02-01), None
patent: WO 01/25272 (2001-04-01), None
patent: WO0125272 (2001-04-01), None
patent: WO0125272 (2001-04-01), None
patent: WO 01/34802 (2001-05-01), None
patent: WO0134802 (2001-05-01), None
patent: WO0134802 (2001-05-01), None
patent: WO 01/40276 (2001-06-01), None
patent: WO0140276 (2001-06-01), None
patent: WO0140276 (2001-06-01), None
patent: WO 01/51633 (2001-07-01), None
patent: WO0151633 (2001-07-01), None
patent: WO0151633 (2001-07-01), None
patent: WO 01/57190 (2001-08-01), None
patent: WO 01/57273 (2001-08-01), None
patent: WO 01/57276 (2001-08-01), None
patent: WO 01/57277 (2001-08-01), None
patent: WO 01/60860 (2001-08-01), None
patent: WO0157190 (2001-08-01), None
patent: WO0157190 (2001-08-01), None
patent: WO0157273 (2001-08-01), None
patent: WO0157276 (2001-08-01), None
patent: WO0157276 (2001-08-01), None
patent: WO0157277 (2001-08-01), None
patent: WO0157277 (2001-08-01), None
patent: WO0160860 (2001-08-01), None
patent: WO0160860 (2001-08-01), None
patent: WO 01/70979 (2001-09-01), None
patent: WO0170979 (2001-09-01), None
patent: WO 01/72962 (2001-10-01), None
patent: WO 01/73032 (2001-10-01), None
patent: WO 01/75067 (2001-10-01), None
patent: WO0172962 (2001-10-01), None
patent: WO0173032 (2001-10-01), None
patent: WO0173032 (2001-10-01), None
patent: WO0175067 (2001-10-01), None
patent: WO0175067 (2001-10-01), None
patent: WO 01/86003 (2001-11-01), None
patent: WO0186003 (2001-11-01), None
patent: WO0186003 (2001-11-01), None
patent: WO 01/94629 (2001-12-01), None
patent: WO 01/96388 (2001-12-01), None
patent: WO0194629 (2001-12-01), None
patent: WO0194629 (2001-12-01), None
patent: WO0196388 (2001-12-01), None
patent: WO 02/10449 (2002-02-01), None
patent: WO 02/16429 (2002-02-01), None
patent: WO0210449 (2002-02-01), None
patent: WO 02/26822 (2002-04-01), None
patent: WO 02/30268 (2002-04-01), None
patent: WO0230268 (2002-04-01), None
patent: WO0230268 (2002-04-01), None
patent: WO 02/057303 (2002-07-01), None
patent: WO02057303 (2002-07-01), None
patent: WO 02/059260 (2002-08-01), None
patent: WO02059260 (2002-08-01), None
patent: WO 02/077013 (2002-10-01), None
patent: WO 02/077186 (2002-10-01), None
patent: WO02077013 (2002-10-01), None
patent: WO02077186 (2002-10-01), None
patent: WO 02/089747 (2002-11-01), None
patent: WO 02/092787 (2002-11-01), None
patent: WO 02/095010 (2002-11-01), None
patent: WO02089747 (2002-11-01), None
patent: WO02092787 (2002-11-01), None
patent: WO02095010 (2002-11-01), None
patent: WO 02/0102993 (2002-12-01), None
patent: WO 02/102993 (2002-12-01), None
patent: WO 02/102994 (2002-12-01), None
patent: WO02102993 (2002-12-01), None
patent: WO02102994 (2002-12-01), None
patent: WO 03/004622 (2003-01-01), None
patent: WO 03/004623 (2003-01-01), None
patent: WO03004622 (2003-01-01), None
patent: WO03004623 (2003-01-01), None
patent: WO 03/009814 (2003-02-01), None
patent: WO03009814 (2003-02-01), None
patent: WO 03/022995 (2003-03-01), None
patent: WO03022995 (2003-03-01), None
Shantz and Pegg (Int J of Biochem and Cell Biol., 1999, vol. 31, pp. 107-122.
McClean and Hill (Eur J of Cancer, 1993, vol. 29A, pp. 2243-2248).
Fu et al (EMBO Journal, 1996, vol. 15, pp. 4392-4401).
Freshney (Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc., 1983, New York, p. 4).
Dermer (Bio/Technology, 1994, 12:320).
Bowie et al. (1990, Science 247:1306-1310, 1990, p. 1306, col. 2).
Abu-Threideh et al., Jun. 1998, EMBL/GENBANK/DDBJ Databases.
Abu-Threideh et al., GENBANK, (Accession No. 095034), National Library of Medicine, Bethesda MD, May 1, 1999.
Alberts et al., Molecular Biology of the Cell, 3rd edition (1994) p. 465.
Bellone et al., Immunology Today (1999) 20(10):457-462.
Bowie et al. (1990) Science 247:1306-1310.
Burgess et al. (1990) Jnl. Cell Biol. 111:2129-2138.
Cate et al., GENBANK, (Accession No. W86309), National Library of Medicine, Bethesda MD, Nov. 1998.
Database EMBL Nucleotide and Protein Sequences, Aug. 25, 1996, XP002128081, AA032221, Hinxton, GB.
Database EMBL Nucleotide and Protein Sequences, May 13, 1997, XP002128082, AC002064, Hinxton, GB.
Database EMBL Nucleotide and Protein Sequences, Jun. 15, 1998, XP002128084, AC004969 (Clone DJ1121E10), Hinxton, GB.
Database EMBL, “Human BAC clone CTB-167B5 form 7q21, complete sequence,” Jun. 17, 1998 XP002173859 (Accession AC 003991 (Waterstone, R.)).
Database EMBL Nucleotide and Protein Sequences, May 1, 1999, XP002128083, O95034 (clone RG041D11), Hinxton, GB.
Diss et al. (1998) “Expression of skeletal muscle-type voltage-gated Na+ channel in rat and human prostate cancer cell lines,” FEBS Letters 427:5-10.
Dulcert et al., GENBANK, (Accession No. Y11840), National Library of Medicine, Bethesda, MD, Feb. 11, 1999.
Falk et al., Nature (1991) 351:390-296.
Fu et al., EMBO Journal (1996) 15:4392-4401.
Greenberg et al., PNAS (1995) 92:3439.
Greenspan et al., (Nature Biotechnology 7:936-937 (1999)).
Grimes et al. (1998) “Electrophysiological characterization of voltage-gated Na+current expressed in the highly metastatic Mat-LyLu cell line of rat prostate cancer,” Journal of Cellular Physiology 175:50-58.
Gura, Science (1997) 278:1041-1042.
Gutierrez et al. (1999) “Activation of a Ca2+-p
Afar Daniel E.
Hubert Rene S.
Mitchell Steven Chappell
Raitano Arthur B.
Saffran Douglas
Canella Karen A.
Conley Deirdre L.
Dreger, Esq. Ginger R.
Genentech Inc.
Heller Ehrman LLP
LandOfFree
Serpentine transmembrane antigens expressed in human cancers... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Serpentine transmembrane antigens expressed in human cancers..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Serpentine transmembrane antigens expressed in human cancers... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3903555