Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-05-24
2011-05-24
Reddig, Peter J (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007210, C435S007230, C530S387100, C530S387700, C530S387900, C530S388100, C530S388800, C530S391100, C530S391300
Reexamination Certificate
active
07947459
ABSTRACT:
Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high'degree of structural conservation among them but show no significant structural homology to any known human proteins. STEAP-2 is a 454 amino acid protein characterized by a predicted molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops.
REFERENCES:
patent: 5001225 (1991-03-01), Taylor
patent: 5571894 (1996-11-01), Wels et al.
patent: 6329503 (2001-12-01), Afar et al.
patent: 6833438 (2004-12-01), Afar et al.
patent: 7319006 (2008-01-01), Afar et al.
patent: 2002/0022248 (2002-02-01), Xu et al.
patent: 2002/0146692 (2002-10-01), Yamazaki et al.
patent: 2002/0192763 (2002-12-01), Xu et al.
patent: 2003/0045682 (2003-03-01), Afar et al.
patent: 2003/0060612 (2003-03-01), Goddard et al.
patent: 2003/0064397 (2003-04-01), Spancake et al.
patent: 2003/0100540 (2003-05-01), Zhang et al.
patent: 2004/0005598 (2004-01-01), DeVaux et al.
patent: 0834563 (1998-04-01), None
patent: 1308459 (2003-05-01), None
patent: 11164691 (1999-09-01), None
patent: 2002-517184 (2003-09-01), None
patent: WO 94/09150 (1994-04-01), None
patent: WO 95/14772 (1995-06-01), None
patent: WO 98/18489 (1998-05-01), None
patent: WO 98/37093 (1998-08-01), None
patent: WO 98/37418 (1998-08-01), None
patent: WO 98/53071 (1998-11-01), None
patent: WO 99/06548 (1999-02-01), None
patent: WO 99/06550 (1999-02-01), None
patent: WO 99/61469 (1999-02-01), None
patent: WO 99/62941 (1999-12-01), None
patent: WO 00/04149 (2000-01-01), None
patent: WO 00/35937 (2000-06-01), None
patent: WO 00/77021 (2000-12-01), None
patent: WO 01/08636 (2001-02-01), None
patent: WO 01/12662 (2001-02-01), None
patent: WO 01/25272 (2001-04-01), None
patent: WO 01/34802 (2001-05-01), None
patent: WO 01/40276 (2001-06-01), None
patent: WO 01/42270 (2001-06-01), None
patent: WO 01/45728 (2001-06-01), None
patent: WO 01/51633 (2001-07-01), None
patent: WO 01/57190 (2001-08-01), None
patent: WO 01/57273 (2001-08-01), None
patent: WO 01/57276 (2001-08-01), None
patent: WO 01/57277 (2001-08-01), None
patent: WO 01/60860 (2001-08-01), None
patent: WO 01/70979 (2001-09-01), None
patent: WO 01/72962 (2001-10-01), None
patent: WO 01/73032 (2001-10-01), None
patent: WO 01/75067 (2001-10-01), None
patent: WO 01/86003 (2001-11-01), None
patent: WO 01/94629 (2001-12-01), None
patent: WO 01/96388 (2001-12-01), None
patent: WO 02/10449 (2002-02-01), None
patent: WO 02/16429 (2002-02-01), None
patent: WO 02/26822 (2002-04-01), None
patent: WO 02/30268 (2002-04-01), None
patent: WO 02/057303 (2002-07-01), None
patent: WO 02/059260 (2002-08-01), None
patent: WO 02/077013 (2002-10-01), None
patent: WO 02/077186 (2002-10-01), None
patent: WO 02/089747 (2002-11-01), None
patent: WO 02/092787 (2002-11-01), None
patent: WO 02/095010 (2002-11-01), None
patent: WO 02/102993 (2002-12-01), None
patent: WO 02/102994 (2002-12-01), None
patent: WO 03/004622 (2003-01-01), None
patent: WO 03/004623 (2003-01-01), None
patent: WO 03/009814 (2003-02-01), None
patent: WO 03/022995 (2003-03-01), None
patent: WO 2005/113601 (2005-12-01), None
patent: WO 2006/034488 (2006-03-01), None
Greenbaum et al. (Genome Biology, 2003, vol. 4, Issue 9, pp. 117.1-117.8).
Brennan et al. (J. Autoimmunity, 1989, 2 (suppl.): 177-186).
Zimmer (Cell Motility and the Cytoskeleton, 1991. 20:325-337).
Hell et al. (Laboratory Investigation, 1995, 73: 492-496).
Fu et al. (EMBO J.; 1996, 15:43982-4401).
Vallejo et al. (Biochimie, 2000 82:1129-1133).
Jang et al. (Clinical Exp. Metastasis, 1997, 15: 469-483).
Bowie et al (Science, 1990: 257:1306-1310).
Coleman et al. (Research in Immunology, 1994; 145(1): 33-36).
Abaza et al. (Journal of Protein Chemistry, vol. 11, No. 5, 1992, pp. 433-444, see abstract in particular).
Roitt et al (1998, Immunology, 4th ed, Mosby).
Holmes (Exp. Opin.Invest. Drugs, 2001, 10(3): 511-519).
Herbert et al. (The Dictionary of Immunology, Academic Press, 4th edition, 1995, p. 58).
Greenspan et al. (Nature Biotechnology 7:936-937, 1999).
Harlow and Lane (Antibodies, a Laboratory Manual, Cold Spring Harbor Laboratory Press, 1988, Ch. 5, p. 76).
Burgess et al (J of Cell Bio. 111:2129-2138, 1990).
Lazar et al (Molecular and Cellular Biology, 1988, 8:1247-1252).
Cruse et al. (Illustrated Dictionary of Immunology, CRC Press, New York, p. 241, 1995).
Dorland's Illustrated Medical Dictionary 26th ed. (W. B. Saunders Co. Philadelphia, 1985, p. 1193).
Abu-Threideh et al., Genbank, (Accession No. 095034), National Library of Medicine, Bethesda MD, May 1, 1999.
Alberts et al., Molecular Biology of the Cell, 3rd edition (1994) p. 465.
Bellone et al., Immunology Today (1999) 20(10):457-462.
Bowie et al. (1990) Science 247:1306-1310.
Burgess et al. (1990) Jnl. Cell Biol. 111:2129-2138.
Cate et al., Genbank, (Accession No. W86309), National Library of Medicine, Bethesda MD, Nov. 1998.
Database EMBL Nucleotide and Protein Sequences, Aug. 25, 1996, XP002128081, AA032221, Hinxton, GB.
Database EMBL Nucleotide and Protein Sequences, May 13, 1997, XP002128082, AC002064, Hinxton, GB.
Database EMBL Nucleotide and Protein Sequences, Jun. 15, 1998, XP002128084, AC004969 (clone DJ1121E10), Hinxton, GB.
Database EMBL, “Human BAC clone CTB-167B5 form 7q21, complete sequence,” Jun. 17, 1998 XP002173859 (Accession AC 003991 (Waterstone, R.)).
Diss et al. (1998) “Expression of skeletal muscle-type voltage-gated Na+ channel in rat and human prostate cancer cell lines,” FEBS Letters 427:5-10.
Dulcert et al., Genbank, (Accession No. Y11840), National Library of Medicine, Bethesda MD, Feb. 11, 1999.
Falk et al., Nature (1991) 351:390-296.
Fu et al., EMBO Journal (1996) 15:4392-4401.
Greenberg et al., PNAS (1995) 92:3439.
Greenspan et al., (Nature Biotechnology 7:936-937 (1999)).
Grimes et al. (1998) “Electrophysiological characterization of voltage-gated Na+current expressed in the highly metastatic Mat-LyLu cell line of rat prostate cancer,” Journal of Cellular Physiology 175:50-58.
Gura, Science (1997) 278:1041-1042.
Gutierrez et al. (1999) “Activation of a Ca2+; -permeable cation channel by two different inducers of appoptosis in a human prostatic cancer cell line,” Journal of Physiology 517.1:95-107.
Haverstick et al. (2000) “Inhibition of human prostate cancer proliferation in vitro and in a mouse model by a compound synthesized to block Ca2+Entry1,” Cancer Research pp. 1002-1008.
Herbert et al. (The Dictionary of Immunology, Academic Press, 4th edition, 1995).
Hubert et al. (1999) PNAS USA 96(25):14523-14528.
Hunt et al., Science (1992) 255:1261-1263.
Lal et al. (US Patent No. 6048970, May 1998, USPTO database sequence listing).
Lazar et al. (1988) Mol. Cell. Biol. 8(3):1247-1252.
Lepple-Wienhues et al. (1996) “K + Channels and the intracellular calcium signal in human melanoma cell proliferation,” J. Membrane Biol. 151:149-157.
Lewin, Genes VI, Oxford University Press, Inc., NY, Chapter 29, 1997.
Marino et al. (1994) “Association between cell membrane potential and breast cancer,” Tumor Biol. 15:82-89.
McClean et al., Eur. J. of Cancer (1993) 29A:2243-2248.
Muller et al., MCB (1991) 11:1785.
Nie et al. (1997) “Inhibition of proliferation of MCF-7 breast cancer cells by a blocker of Ca2+-permeable channel,” Cell Calcium 22(2):75-82.
Pancrazio et al. (1989) “Voltage-dependent ion channels in small-cell lung cancer cells1,” Cancer Research 49:5901-5906.
Parker et al., J. Immunol. (1994) 152:163-175.
Peshwa et al., Prostate (1998) 36:129-138.
Rama et al.. Biochem. J. 318:333-341 (1996).
Rieger et al., Glossary of Genetics
Afar Daniel E. H.
Faris Mary
Hubert Rene S.
Jakobovits Aya
Mitchell Steven Chappell
Agensys, Inc.
Dreger Ginger R.
Kresnak Mark T.
Popp, JD, LLM Shane M.
Reddig Peter J
LandOfFree
Serpentine transmembrane antigens expressed in human cancers... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Serpentine transmembrane antigens expressed in human cancers..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Serpentine transmembrane antigens expressed in human cancers... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2622176