Serotonin 5-HT3 receptor agonist

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S383000, C544S390000, C544S391000

Reexamination Certificate

active

07485646

ABSTRACT:
A serotonin 5-HT3 receptor agonist containing a compound represented by the general formula (1) [R1, R3and R5represent hydrogen atom, a lower alkyl group, a lower alkenyl group, a halogen atom, hydroxyl group, amino group, a lower alkoxy group, carboxyl group, carbamoyl group, or nitro group, R2and R4represent a halogen atom, hydroxyl group, or amino group, R6represents hydrogen atom, a lower alkyl group, or a lower alkenyl group, R7represents hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group, and m and n are integers of 1 to 3] or a physiologically acceptable salt thereof as an active ingredient and having both a serotonin 5-HT3 receptor antagonistic action and a serotonin 5-HT3 receptor activating action.

REFERENCES:
patent: 4252804 (1981-02-01), Joullié et al.
patent: 5631257 (1997-05-01), Iwamatsu et al.
patent: 6037342 (2000-03-01), Sato et al.
patent: 2004/0006091 (2004-01-01), Kyle et al.
patent: 2004/0044003 (2004-03-01), Kyle et al.
patent: 2007/0249618 (2007-10-01), Folmer et al.
patent: 53-135945 (1978-11-01), None
patent: 6-345744 (1994-12-01), None
patent: 10-029987 (1998-02-01), None
patent: 97/28141 (1997-08-01), None
patent: 98/31677 (1998-07-01), None
patent: 03/066595 (2003-08-01), None
English Language Abstract of JP 10-029987.
English Language Abstract of JP 6-345744.

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