Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2009-05-05
2010-10-19
Bernhardt, Emily (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S364000
Reexamination Certificate
active
07816362
ABSTRACT:
Novel piperazine derivatives are provided having the formulawherein R1is cyano, nitro, trifluoromethyl or halogen, or pharmaceutically acceptable acid addition salts thereof, which are useful as 5-HT1Areceptor antagonists.
REFERENCES:
patent: 5532244 (1996-07-01), Wong et al.
patent: 5532250 (1996-07-01), Wong et al.
patent: 5532264 (1996-07-01), Wong et al.
patent: 5532268 (1996-07-01), Wong et al.
patent: 5538992 (1996-07-01), Wong et al.
patent: 5552429 (1996-09-01), Wong et al.
patent: 5710149 (1998-01-01), Cliffe et al.
patent: 5756532 (1998-05-01), Stack et al.
patent: 5776969 (1998-07-01), James
patent: 6127357 (2000-10-01), Cliffe et al.
patent: 6169105 (2001-01-01), Wong et al.
patent: 6172062 (2001-01-01), Clark et al.
patent: 6459007 (2002-10-01), Santi et al.
patent: 6469007 (2002-10-01), Childers et al.
patent: 6566112 (2003-05-01), Jones et al.
patent: 6586436 (2003-07-01), Childers et al.
patent: 6713626 (2004-03-01), Feigelson et al.
patent: 7026320 (2006-04-01), Childers et al.
patent: 7425558 (2008-09-01), Rizzo et al.
patent: 2003/0204087 (2003-10-01), Chan et al.
patent: 2004/0230056 (2004-11-01), Feigelson et al.
patent: 2005/0209245 (2005-09-01), Chan et al.
patent: 2005/0215561 (2005-09-01), Ghosh et al.
patent: 0 512 755 (1992-11-01), None
patent: 0 687 472 (1995-12-01), None
patent: 0 792 649 (1997-09-01), None
patent: WO-94/13643 (1994-06-01), None
patent: WO-94/13644 (1994-06-01), None
patent: WO-94/13661 (1994-06-01), None
patent: WO-94/13676 (1994-06-01), None
patent: WO-94/13677 (1994-06-01), None
patent: WO-95/33725 (1995-12-01), None
patent: WO-95/33743 (1995-12-01), None
patent: WO-97/03982 (1997-02-01), None
patent: WO-02/44142 (2002-06-01), None
patent: WO-03/078396 (2003-09-01), None
patent: WO-03/078417 (2003-09-01), None
patent: WO-2004/082686 (2004-09-01), None
Alexandre et al., 2006, “Early Life Blockage of 5-Hydroxytryptamine 1A Receptors Normalizes Sleep and Depression-Like Behavior in Adult Knock-Out Mice Lacking the Serotonin Transporter”, J. of Neuroscience, 26(20):5554-5564.
Artigas et al., 1996, “Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists”, Trends Neurosci. 19(9):378-383.
Azmitia, 2001, “Neuronal Instability: Implications for Rett's Syndrome”, Brain & Development, 23:S1-S10.
Balant, et al., 1995, “Metabolic Considerations in Prodrug Design”Burger's Medicinal Chemistry and Drug Discovery, Fifth Edition, vol. 1, Wolff, ed., John Wiley & Sons, pp. 949-982.
Baldwin, 2004, “Sexual Dysfunction Associated with Antidepressant Drugs”, Expert Opin. Drug Saf., 3(5):457-470.
Berends et al., 2005, “A Review of the Neuroprotective Properties of the 5-HT1A Receptor Agonist Repinotan HCI (BAY x 3702) in Ischemic Stroke”, CNS Drug Reviews 11(4):379-402.
Beresford, et al., 2003, “Treatments for Stroke”, Expert Opin. Emerging Drugs, 8(1):103-122.
Blackburn, 2004, “Serotonergic Agents and Parkinson's Disease”, Drug Discovery Today: Therapeutic Strategies, 1(1):35-41.
Blanchard et al., 1997, “An Ethopharmacological Analysis of Selective Activation of 5-HT1A Receptors: The Mouse 5-HT1A Syndrome”, Pharmacology Biochem. and Behavior, 57(4):897-908.
Boast et al., 1999, “5HT Antagonists Attenuate MK801-Impaired Radial Arm Maze Performance in Rats”, Neurobiol. Learning Memory, 71:259-271.
Borg, et al., 2006, “Search for Correlations between Serotonin 5-HT1A, Receptor Expression and Cognitive Functions—a Strategy in Translational Psychopharmacology”, Psychopharmacology, 185:389-394.
Cao et al., 1998, “Tolerance to acute anxiolysis but no withdrawal anxiogenesis in mice treated chronically with 5-HT1A receptor antagonist, WAY 100635”, Neuroscience and Biobehavioral Reviews, 23:247-257.
Cao, 1997, “Influence of 5-HT1A Receptor Antagonism on Plus-Maze Behaviour in Mice”, Pharmacology Biochem. and Behavior, 58(2):593-603.
Carli et al., 1995, “(S)-WAY-100135, a 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine”, European J. Pharmacology, 283:133-139.
Carli et al., 1997, “WAY 100635, a 5-HT1AReceptor Antagonist, Prevents the Impairment of Spatial Learning Caused by Intrahippocampal Administration of Scopolamine or 7-Chloro-Kynurenic Acid”, Brain Res. 774:167-174.
Carli et al., 1999, “WAY 100635, a 5-HT1Areceptor antagonist, prevents the impairment of spatial learning caused by blocade of hippocampal NMDA receptors”, Neuropharmacol. 38:1165-1173.
Carli et al., 2000, “The 5-HT1AReceptor Agonist 8-OH-DPAT Reduces Rats' Accuracy of Attentional Performace and Enhances Impulsive Responding in a Five-Choice Serial Reaction Time Task: Role of Presynaptic 5-HT1AReceptors”, Psychopharmacol., 149:259-268.
Cheeta et al., 2001, “The dorsal raphe nucleus is a crucial structure mediating nicotine's anxiolytic effects and the development of tolerance and withdrawal responses”, Psychopharmacology, 155:78-85.
Childers, et al., 2005, “Synthesis and Biological Evaluation of Benzodioxanylpiperazine Derivatives as Potent Serotonin 5-HT1AAntagonists: The Discovery of Lecozotan”, J. Med. Chem., 48:3467-3470.
Collinson et al., 1997, “On the elevated plus-maze the anxiolytic-like effects of the 5-HT(1A) agonist, 8-OH-DPAT, but not the anxiogenic-like effects of the 5-HT(1A) partial agonist, buspirone, are blocked by the 5-HT1A antagonist, WAY 100635”, Psychopharmacology (Berl). 132(1):35-43.
Cryan et al., 1999, “Comparative effects of serotonergic agonists with varying efficacy at the 5-HT1A receptor on core body temperature: modification by the selective 5-HT1A receptor antagonist WAY 100635”, J. Psychopharmacol., 13:278-283.
Dijk et al., 1995, “NMDA-induced glutamate and aspartate release from rat cortical pyramidal neurons; evidence for modulation by a 5-HT1A antagonist”, British J. of Pharmacology, 115:1169-1174.
Dunlop, et al., 1998, “Characterization of 5-HT1AReceptor Functional Coupling in Cells Expressing the Human 5-HT1AReceptor as Assessed with the Cytosensor Microphysiometer”, J. Pharmacol. Tox. Methods, 40:47-55 (1998).
Duxon et al., 2000, “Latency to paroxetine-induced anxiolysis in the rat is reduced by co-administration of the 5-HT1A receptor antagonist WAY100635”, British J. of Pharmaco., 130:1713-1719.
Ellingrod, et al., 1996, “Letters: Reassessment of Nefazodone”, Amer. Journal of Healt-System Pharmacy, 53(19):2339-2340, 2343.
Ellingrod, et al., 1996, “Nefazodone: A New Antidepressant”, Am. J. Health Syst. Pharm., 52:2799-2812.
European Examination Report for European Patent Application No. 06736178.2 mailed Jul. 29, 2008.
Fletcher et al., 1996, “Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist”, Behav. Brain Res., 73:337-353.
Gudelsky et al., 1986, “Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat”, Neuropharmacology, 25(12):1307-1313.
Harder et al., 2000, “The 5-HT1A antagonist, WAY 100 635, alleviates cognitive impairments induced by dizocilpine (MK-801) in monkeys”, Neuropharmacol., 39:547-552.
Hjorth et al., 1997, “WAY 100653-induced Augmentation of the 5-HT-elevating Action of Citalopram: Relative Importance of the Dose of the 5-HT1A Auto)receptor Blocker Versus that of the 5-HT Reuptake Inhibitor”, Neuropharmacology, 36(4/5):461-465.
Hollander, et al., 1992, “Yohimbine Treatment of Sexual Side Effects Induced by Serotonin Reuptake Blockers”, J. Clin Psychiatry, 53(6):207-209.
Hughes et al., 1991, “Symptoms of Tobacco Withdrawal”, Arch. Gen. Psychiatry 48:52-59.
Hutson et al, 1988, “Evidence that the hyperphagic response to 8-OH-DPAT is mediated by 5-HT1A re
Childers Wayne Everett
Kelly Michael
Rosenzweig-Lipson Sharon Joy
Bernhardt Emily
Kispert Jennifer
Lodovice Ian J. S.
Wyeth LLC
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