Seroreactive regions on HPV 16 proteins E1 and E2

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

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4241851, 4241861, 4242041, 435 693, 4351723, 514 2, 530300, 530350, 530324, 530327, 930220, A61K 3912, A61K 3900, C07K 500, C12N 1500

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056019734

ABSTRACT:
The invention relates to seroreactive regions on proteins E1 and E2 of human papillomavirus (HPV) 16.
The application also relates to a vaccine which contains such peptides which contain the seroreactive regions.
The invention likewise embraces compositions for diagnostic purposes which contain peptides with the seroreactive regions.

REFERENCES:
patent: 4554101 (1985-11-01), Hopp
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Human Papillomavirus Type 16 DNA Sequence, K. Seedorf et al., Virology 145, pp. 181-185, 1985.
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Gene-III Protein Of Filamentous Phages: Evidence For A Carboxyl-Terminal Domain With A Role In Morphogenesis, J. Crissman et al., Virology 132, pp. 445-455, 1984.
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Hopp, T. P. Peptide Research 6(4) 183-190 (1993).
Hopp Analysis.
Lees, E. M. et al. Eur. J. Biochem 190: 85-92 (1990).
J. Dillner, "Mapping of Linear Epitopes of Human Papillomavirus Type 16: the E1, E2, E4, E5, E6 and E7 Open Reading Frames," Int. J. Cancer, vol. 46, 703-711 (1990).
A. J. Cumber et al., "Preparation of Antibody-Toxin Conjugates," Methods in Enzymology, vol. 112, 207-225 (1985).

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