Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1995-06-06
1998-05-19
Smith, Lynette F.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4241841, 435 5, 435 71, A61K 3912, A61K 3900, C12Q 170, G01N 3353
Patent
active
057532338
ABSTRACT:
The invention relates to seroreactive epitopes on proteins of human papillomavirus HPV18.
In addition, the invention relates to peptides which have amino-acid sequences which coincide in whole or in part with the sequences of the seroreactive epitopes, and to vaccines which contain such peptides.
REFERENCES:
patent: 4777239 (1988-10-01), Schoolnik et al.
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Selvey, L.A., et al., "Identification of B-Epitopes in the Human Papillomavirus 18 E7 Open Reading Frame Protein," The Journal of Immunology, vol. 145, No. 9, pp. 3105-3110 (1990).
Smith, G. P., "Filamentous Fusion Phage: Novel Expression Vectors That Display Cloned Antigens on the Virion Surface," Science 228:1315-1317 (1985).
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Matlashewski, G. et al., The Expression of Human Papillomavirus Type 18 E6 Protein in Bacteria and the Production of Anti-E6 Antibodies, J. Gen. Virol. 67:1909-1916 (1986).
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Sanger, F. et al., "DNA sequencing with chain-terminating inhibitors," Proc. Natl. Acad. Sci. USA, vol. 74:5463-5467 (1977).
Bleul, C. et al., "Human Papillomavirus Type 18 E6 and E7 Antibodies in Human Sera: Increased Anti-E7 Prevalence in Cervical Cancer in Patients," Journal of Clinical Microbiology, vol. 29, 1579-1588 (1991).
Cole, S.T. et al., "Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of E6 and E7 gene products," Chem. Abstracts 107:53075n (1987).
Durst, M. et al., "A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions," Proc. Natl. Acad. Sci., USA, vol. 80, pp. 3812-3815 (1983).
Geysen, H.M. et al., "Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein," Proc. Natl. Acad. Sci. USA, vol. 82:178-182 (1985).
Geysen et al., "Use of peptide synthesis to probe viral antigens for epitopes to resolution of a single amino acid," Proc. Natl. Acad. Sci., USA, vol. 81:3998-4002, (1984).
Bleul Conrad
Gissmann Lutz
Muller Martin
Behring Diagnostics GmbH
Smith Lynette F.
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