Serological detection of antibodies to HTLV-III in sera of patie

Chemistry: analytical and immunological testing – Biospecific ligand binding assay – Utilizing isolate of tissue or organ as binding agent

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436510, 436515, 436530, 436531, 436543, 436804, 436808, 436809, 436811, 436546, 435 5, 435 7, 435194, 435239, 435810, 435948, 422 61, 424 86, 424 89, G01N 3354, G01N 3356

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045201137

ABSTRACT:
This invention relates to the detection of antibodies in sera of AIDS and pre-AIDS patients and describes the biochemical and immunological analysis of antigens associated with the virus HTLV-III Human T-Cell Leukemia Virus. It is shown that antigens associated with the infection of human cells by this virus are specifically recognized by antibodies from AIDS patients. Specifically, HTLV-III isolated from AIDS patients and transmitted by cocultivation with an HT cell line is specifically detected by antibodies from human sera taken from AIDS patients. The method of detection of antibodies preferred is a strip radioimmunoassay (RIA) based on the Western Blot technique or an ELISA (an enzyme-linked immunosorbent assay) or an indirect immunofluorescence assay.

REFERENCES:
Robert-Guroff, M. et al., Science, vol. 215, pp. 975-978, (2-1982).
Essex, M. et al., Science, vol. 220, pp. 859-862, (5-1983).
Gallo, R. C. et al., Science, vol. 220, pp. 865-867, (5-1983).
Barre-Sinoussi, F. et al., Science, vol. 220, pp. 868-871, (5-1983).
J. National Cancer Institute, vol. 69(4), pp. 981-985, (10-1982), Essex, M.
Posner, L. E. et al., J. Experimental Medicine, vol. 154, pp. 333-346, (8-1981).
Hinuma, Y. et al., Proc. Natl. Acad. Sci. USA, vol. 78(10), pp. 6476-6480, (10-1981).
Kalyanaraman, V. S. et al., Nature, vol. 294, pp. 271-273, (11-1981).
Marx, J. L., Science, vol. 224, pp. 475-477, (5-1984). (Not Prior Art).
Sarngadharan, M. G. et al., Science, vol. 224, pp. 506-508, (5-1984). (Not Prior Art).
Schupbach, J. et al., Science, vol. 224, pp. 503-505, (5-1984). (Not Prior Art).
Gallo, R. C. et al., Science, vol. 224, pp. 500-503, (5-1984). (Not Prior Art).
Popovic, M. et al., Science, vol. 224, pp. 497-500, (5-1984). (Not Prior Art).
Jaffe, H. W. et al., Science, vol. 223(4642), pp. 1309-1312, (3-1984).
Mitsuya, H. et al., Science, vol. 223(4642), pp. 1293-1296, (3-1984).
Leavitt, R. D., Eur. J. Clin. Microbiol., vol. 3(1), pp. 79-84, (2-1984).
Kalyanaraman, V. S. et al., Virology, vol. 132, pp. 61-70, (1984).
Kreise, J. K. et al., Annals Int. Medicine, vol. 100, pp. 178-182, (1984).
Brun-Vezinet, F. et al., The Lancet, I, pp. 1253-1256, (6-1984). (Not Prior Art).
Kalyanaraman, V. S. et al., Science, vol. 225, pp. 321-323, (7-1984). (Not Prior Art).
Tsang, V. C. W. et al., Methods in Enzymology, vol. 92, pp. 377-391, (1983).
Saxinger, C. et al., Laboratory Investigation, vol. 49(3), pp. 371-377, (1983).
de The, G. et al., C. R. Acad. Sc. Paris III, vol. 297(4), pp. 195-197, (10-1983).
Evatt, B. L. et al., The Lancet, vol. 2(8352), pp. 698-700, (1983).
Essex, M. et al., Science, vol. 221(4615), pp. 1061-1064, (9-1983).
Gelmann, et al., Science, 220:862-865, May 20, 1983.

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