Serine threonine kinase member, h2520-59

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

Reexamination Certificate

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C424S094500, C435S252300, C435S320100, C530S350000

Reexamination Certificate

active

07029892

ABSTRACT:
The present invention relates to a serine threonine kinase. The invention also relates to nucleic acids encoding the kinase, vectors, host cells, antibodies and recombinant methods for producing the h2520-59 polypeptide. In addition, the invention discloses therapeutic, diagnostic and research utilities for h2520-59 and related products.

REFERENCES:
patent: 6387676 (2002-05-01), Virca et al.
patent: 6638721 (2003-10-01), Meyers et al.
patent: WO 00/08180 (2000-02-01), None
patent: WO 00/55350 (2000-09-01), None
Hanks et al., “The protein kinase family: conserved features and deduced phylogeny of the catalytic domains,”Science241:42-52, 1988.
Cross et al., “Serine/threonine protein kinases and apoptosis,”Exp Cell Res256:34-41, 2000.
Mayumi-Matsuda et al., “Identification of a novel kinase-like gene induced during neuronal cell death,”Biochem Biophys Res Comm258: 260-264, 1999.
Database GenBank. National Library of Medicine, (Bethesda, Maryland, US), AN AL034548, Blakey, Human DNA sequence from clone RP5-1103G7 on chromosome 20p12.2-13, 2001.
Database GenBank. National Library of Medicine, (Bethesda, Maryland, US), AN AK026945, Kawabata et al., Homo sapiens cDNA: FLJ23292 fis, clone HEP10334, NEDO human cDNA sequencing project, 2000.
Seher et al., “Tribbles, a cell-cycle brake that coordinates proliferation and morphogenesis duringDrosophilagastrulation,”Curr Biol10:623-629, 2000.
Mata et al., “Tribbles coordinates mitosis and morphogenesis inDrosophilaby regulating string/cdc25 proteolysis,”Cell101:511-522, 2000.
Grosshans et al., “A genetic link between morphogenesis and cell division during formation of the ventral furrow inDrosophila,” Cell101:523-531, 2000.

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