Serine-rich peptide linkers

Details Serine-rich peptide linkers Serine-rich peptide linkers

1994-06-09

1996-06-11

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 4353201, 530350, 5303873, 536 234, C07K 1646, C12N 1562

Patent

active

055254918

ABSTRACT:
Disclosed are serine-rich peptide linkers for linking two or more protein domains to form a fused protein. The peptide linkers contains at least 40% serine residues and preferably have the formula (Ser, Ser,Ser,Ser,Gly).sub.y where y is .gtoreq.1. The resulting fused domains are biologically active together or individually, have improved solubility in physiological media, and improved resistance to proteolysis.

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