Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-07
1998-04-07
Johnson, Jerry D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
435 681, 435212, 435213, 435214, 435215, 435216, 435217, 435218, 435219, 435220, 435221, 435222, 435223, 435224, 435225, 435226, 530338, 530345, 530409, 530410, A61K 3800, C12P 2106, C07K 117
Patent
active
057365121
ABSTRACT:
The invention relates to serine protease variants derived from precursor serine proteases via recombinant and/or chemical methods to form protease variants having improved peptide ligase activity. The invention also includes novel ligation substrates which in combination with the serine protease variants and a second ligation substrate are capable of forming a ligation product. The invention also relates to methods for forming such ligation products and the products formed thereby.
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Caldwell, R., et al., "Analysis of the Catalytic Importance of a Helix Dipole in Subtilisin Using Site-Directed Mutagenesis", American Chemical Society Abstract MBTD-73, Sep. 10-15, 1989.
Carter, P., et al., "Dissecting the Catalytic Triad of a Serine Protease", Nature,332 (7) :564-568 (1988).
Abrahmsen, L., et al., "Engineering Subtilisin and Its Substrates for Efficient Ligation of Peptide Bonds in Aqueous Solution", Biochemistry, 30:4151-4159 (1991).
Abrahmsen Lars
Burnier John
Jackson David T.
Wells James A.
Genentech Inc.
Johnson Jerry D.
Trecartin Richard F.
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