Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1990-09-28
1994-04-19
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435212, 4351723, 536 232, C12N 964, C12N 1500, C12N 1558
Patent
active
053044827
ABSTRACT:
The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
REFERENCES:
patent: 5108901 (1992-04-01), Anderson
Petersen et al., Biochemistry 29: 3451-3457 (1990).
Rickles et al, J. Biol. Chem., 263:1563-1569 (1988).
Ny et al, DNA, 7:671-677 (1988).
Gardell et al, J. Biol. Chem., 264:17947-17952 (1989).
Strassburger et al, FEBS, 157:219-223 (1983).
Gething Maryjane H.
Goldsmith Elizabeth J.
Madison Edwin L.
Sambrook Joseph F.
Schwartz Richard A.
The Board of Regents of the University of Texas System
Vogel Nancy T.
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