Serine protease inhibitors-tripeptoid analogs

Details Serine protease inhibitors-tripeptoid analogs Serine protease inhibitors-tripeptoid analogs

1997-12-04

2000-11-21

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, A61K 3806, C07K 5083

Patent

active

061503347

ABSTRACT:
The present invention relates to certain compounds comprising substituted oxadiazole, thiadiazole and triazole structures which are useful as inhibitors of serine proteases, including human neutrophil elastase (HNE). Compounds described herein are characterized by their relatively low molecular weight, high potency and selectivity with respect to HNE, and can be used to effectively prevent, alleviate or otherwise treat disease states characterized by the degradation of connective tissue by proteases in humans.

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