Serine protease inhibitors comprising .alpha.-keto heterocycles

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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435 11, 514 18, 514 19, 514 20, 514361, 514362, 514363, 514364, 514383, 530330, 530331, 530332, 548128, 548131, 548136, 548143, 5482668, 5482682, A61K 3805, A61K 3806, A61K 3807, A61K 3808

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active

061599387

ABSTRACT:
Provided are methods of inhibiting the activity of a serine protease using protease inhibitors that include an alpha-keto heterocycle in their structure. The methods are useful in the treatment of ischemic heart or treatment of symptoms associated with blood coagulation disorders. Also provided are methods for detecting or quantifying the activity of a serine protease in a pure sample.

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