Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-07-19
2005-07-19
Raymond, Richard L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S539000, C514S562000, C514S601000, C514S602000, C514S603000, C514S604000, C514S605000, C549S063000, C549S065000, C560S013000, C562S430000, C564S080000, C564S084000, C564S086000, C564S087000, C564S091000, C564S092000, C564S099000
Reexamination Certificate
active
06919369
ABSTRACT:
Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.
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Glunz et al., Chemical Abstracts, vol. 141:225834, 2004.
Renatus et al., “Structural and Functional Analyses of Benzamidine-Based Inhibitors in Complex with Trypsin: Implications for the Inhibition of Factor Xa, tPA, and Urokinase”J. Med. Chem. 41:5445-5456 (1998).
Aliagas-Martin Ignacio
Artis Dean R.
Dina Michael S.
Flygare John A.
Goldsmith Richard A.
Andrus Alex
Evans David W.
Genentech Inc.
Raymond Richard L.
Schwartz Timothy R.
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