Serine protease inhibitor analogs

Details Serine protease inhibitor analogs Serine protease inhibitor analogs

1994-07-29

1999-05-04

Teng, Sally

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 530300, 530324, 530854, 530350, 435 692, 4351721, 435213, 435218, A61K 3855, C12N 1515, C07K 1481

Patent

active

059004002

ABSTRACT:
Analogs of the serine protease inhibitors in which the amino acid sequence is varied slightly are disclosed, which analogs variously show improved properties including improved resistance to oxidative inactivation, improved ability to inhibit pancreatic elastase, improved ability to inhibit cathepsin G, and improved ability to inhibit trypsin.

REFERENCES:
patent: 4394443 (1983-07-01), Weissman et al.
patent: 4511503 (1985-04-01), Olson et al.
patent: 4530901 (1985-07-01), Weissman
patent: 4546082 (1985-10-01), Kurgan et al.
patent: 4595674 (1986-06-01), Tschesche
patent: 4626510 (1986-12-01), Grandi
patent: 4652639 (1987-03-01), Stabinsky
patent: 4672032 (1987-06-01), Slavkin et al.
patent: 4711848 (1987-12-01), Insley et al.
patent: 4720454 (1988-01-01), White et al.
patent: 4760130 (1988-07-01), Thompson et al.
patent: 4788135 (1988-11-01), Davis et al.
patent: 4845076 (1989-07-01), Heinzel
patent: 4923807 (1990-05-01), Webb et al.
patent: 4952512 (1990-08-01), Loskutoff et al.
patent: 5102995 (1992-04-01), Tollefsen et al.
patent: 5109113 (1992-04-01), Caras et al.
patent: 5151438 (1992-09-01), Sham et al.
patent: 5157019 (1992-10-01), Glover et al.
patent: 5196404 (1993-03-01), Maraganore et al.
patent: 5215915 (1993-06-01), Tiberi et al.
patent: 5252725 (1993-10-01), Rubin et al.
patent: 5376633 (1994-12-01), Lezdey et al.
patent: 5532215 (1996-07-01), Lezdey et al.
Ohlsson et al., Chemical Abstracts, (1983), No. 99:173443.
Eisenberg, S.P., et al., "Location of the Protease-inhibitory Region of Secretory Leukocyte Protease Inhibitor," The Journal of Biological Chemistry, 265:7976-7981 (1990).
Wong, Y. N., et al. (1994), "A pharmacokinteic evaluation of HIV protease inhibitors, cyclic ureas, in rats and dogs," Biopharmaceutics & Drug Disposition, 15:535-544.
Dorsey, B. D., et al. (1994), "Synthesis and evaluation of pyridyl analogs of L-735,524: Potent HIV-1 portease inhibitors," Bioorganic & Medicinal Chemistry Letters, 4:2769-2774.
Rose, J. R., et al. (1994), "Structure-assisted design of nonpeptide human immunodeficiency virus-1 protease inhibitors," American Journal of Respiratory and Critical Care Medicine, 150:S176-S182.
Chen, Z., et al. (1995), "Three-dimensional structure if a mutant HIV-1 protease displaying cross-resistance to all protease inhibitors in clinical trials," The Journal of Biological Chemistry, 270:21433-21436.
Maschera, B., et al. (1995), "Analysis of resistance to human immunodeficiency virus type --protease inhibitors by using matched bacterial expression and proviral infection vectors," Journal of Virology, 69:5431-5436.
Amann et al. (1983), "Vectors bearing a hybrid trp-lac promoter userful for regulated expression of cloned genes in Escherichia coli," Gene, 25:167-178.
Anderson et al. (1983), "Isolation of a genomic clone for bovine pancreatic trypsin inhibitor by using a unique-sequence synthetic DNA probe," Proc. Natl. Acad. Sci. USA, 80:6838-6842.
Botstein et al. (1982), "Principles and Practice of Recombinant DNA Research with Yeast," The Molecular Biology of the Yeast Sacchromyces, 607-636.
Brake et al. (1984), ".alpha.-Factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae," Proc. Natl. Acad. Sci. USA, 81:4642-4646.
Fritz (1988), "Human Mucus Proteinase Inhibitor (Human MPI)," Biol. Chem. Hoppe-Seyler, 369:79-82.
Fritz et al. (1978), "Naturally Occurring Low Molecular Weight Inhibitors of Neutral Proteinases from PMN-Granulocytes and of Kallikreins," Agents and Actions, 8/1-2:57-64.
Kurachi et al. (1981), "Cloning and sequence of cDNA coding for a.sub.1 -antitrypsin," Proc. Nat'l. Acad. Sci. USA, 78:6826-6830.
Landau et al. (1984), "Cloning of a terminal transferaase cDNA by antibody screening," Proceedings, National Academy of Sciences USA, 81:5836-5840.
Leicht et al. (1982), "Sequence homology and structural comparison between the chromosomal human a.sub.1 -antitrypsin and chicken ovalbumin genes," Nature, 297:655-659.
Leytus et al. (1984), "Characterization of cDNA coding for human factor X," Proceedings, National Academy of Sciences USA, 81:3699-3702.
Lovett et al. (1979), "Bacillus subtilis as a Host for Molecular Cloning," Methods in Enzymology, 68:342-357.
Maniatis (1982), Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory Press, p. 231.
Maniatis (1982), Molecular Cloning, A Laboratory Manual, Cold spring Harbon Laboratory Press, pp. 190-193.
Miller et al. (1981), "Synthesis of Biologically Active Proteins by Recombinant DNA Technology," Drug Development Research, 1:435-454.
Ohlsson et al. (1977), "Isolation and Partial Charcterization of a Low Molecular Weight Acid Stable Protease Inhibitor from Human Bronchial Secretion," Hoppe-Seyler's Z. Physiol. Chem., 358:583-589.
Ohlsson et al. (1983), "Quantification of Granulocyte Elastase Inhibitors in Human Mixed Saliva and in Pure Parotid Secretion," Hoppe-Seyler's Z. Physiol. Chem., 364:1323-1328.
Ohlsson et al. (1984), "Localization of antileukoprotease in the parotid and the submandibular salivary glands," Biological Abstracts, 78:ref. No. 90008 and Acta Otolaryngol (Stockh) (1984), 98:147-151.
Alberts et al. (1983), "Recombinant DNA Technology," Molecular Biology of the Cell, Garland Publishing Inc., pp. 185-196.
Rogers et al. (1983), "The Isolation of a Clone for Human a 1-Antitrypsin and the Detection of a 1-Antitrypsin in mRNA From Liver and Leukocytes," Biochem and Biophysical Res. Commun., 116(2):375-382.
Schiessler et al. (1976), "Inhibitors of Acrosin and Granulocyt-Proteinase from Human Genital Tract Secretions," Hoppe-Seyler's Z. Physiol. Chem. Bd., 357:1251-1260.
Schiessler et al., "Acid-stable inhibitors of granulocyte neutral proteases in human mucous secretions: biochemistry and possible biological function," Chemical Abstracts, 89:192866u (1978) and Neutral Proteases of Human Polymorphonuclear Leukocytes, Urban & Schwarzenberg, Baltimore/Munich, pp. 195-207 (1978).
Schiessler et al. (1979), "Inhibitors of granulocyte protease (antileukoprotease) in human genital tract secretions," Chemical Abstracts, 90: abstract No. 117084e and Human Fertilization, Georg Thieme Publishers, Stuttgart (1978), pp. 101-106.
Seemuller et al. (1986), "The acid-stable proteinase inhibitor of human mucous secretions (HUSI-I, antileukoprotease)," FEBS Lett., 199:43-48.
Stetler et al. (1986), "Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases," Nucleic Acids Research, 14(20) :7883-7896.
Travis et al. (1983), "Human Plasma Proteinase Inhibitors," Ann. Rev. Biochem., 52:655-709.
Valenzuela et al. (1982), "Synthesis and assembly of hepatitis B virus surface antigen particles in yeast," Nature, 298:347-350.
Young et al. (1983), "Efficient isolation of genes by using antibody probes," Proc. Natl. Acad. Sci. USA, 80:1194-1198.
Wallner et al. (1974), "Characterization of an Acid-Stable Proteinase Inhibitor in Human Cervical Mucus," Hoppe-Seyler's Z. Physiol. Chem. Bd., 355:709-715. Secretory Leukocyte Protease Inhibitor by Saccharomyces Cerevisiae," Bio/Technology, 7(1):55-60.
Smith et al. (1985), "Human bronchial leucocyte proteinase inhibitor," Biochem. Journal, 225:463-472.
Lucey et al. (1990), "Recombinant human secretory leukocyte-protease inhibitor; In vitro properties, and amelioration of human neutrophil elastase-induced emphysema and secretory cell metaplasia in the hamster,"J. Lob. Clin. Med., 115/2:224-232.
Birrer et al. (1992), "Intravenous recombinant secretory leukoprotease inhibitor augments antineutrophil elastrase defense," Journal of Applied Physiology, 73/1:317-323.
Klasen, et al. (1985), "The N-Terminal Sequence of Antileukoprotease Isolated from Bronchial Secretion," Chemical and Biophysical Research Communications, 128/1:285-289.
Movva, et al. (1980), "Gene Structure of the OmpA Protein, a Major Surface Protein of Escherichia coli Required for Cell-Cell Interaction," J. Mol. Biol., 143:317-328.
Whitson, et al. (1986), "Thermodynamic Analysis of the Lactose Repressor--Operator DNA Interaction," Biochemistry, 25:3852-3858.
Whitson, et al. (1986), "Dissociation of the Lactose Represso

Affiliated with

Also associated with

Rating

Serine protease inhibitor analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Serine protease inhibitor analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Serine protease inhibitor analogs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1869572