Serine protease genes related to DPPIV

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase

Reexamination Certificate

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C435S226000, C435S212000, C435S069100, C530S350000, C536S023200

Reexamination Certificate

active

10982512

ABSTRACT:
Novel proteins or polypeptides having significant sequence homology to DPPIV, nucleic acids coding therefor, cells which have been modified with such nucleic acid so as to express these proteins, antibodies to these proteins, screening methods for the discovery of new therapeutic agents which are inhibitors of the activity of these proteins or of related proteins, and therapeutic agents discovered by such screening methods, as well as new therapeutic treatments, are all provided.

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patent: WO 01/55399 (2001-08-01), None
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BenBank Accession No. P27487, 2 Aug. 1, 1992.
GenBAnk Accession No. BAC34034, Jul. 16, 2001.
GenBank Accession No. AK050021, Jul. 16, 2001.
Abbott, et al.; “Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DDP) IV homology”, DPP8, Eur. J. Biochem. 267, 6140—6140 (2000).
Nagase, T., et al.; “Prediction of the Coding Sequences of Unidentified Human Genes”, DNA Research, Universal Academy Press, JP, vol. 7, No. 2, Apr. 28, 2000.
Swallprot ‘Online!’ Oct. 1, 2000, EBI Database accession No. Q9P236 (2 pages).
Yokotani, N., et al.; “Non-Conservation of a Catalytic Residue in a Dipeptidyl Aminopeptidase IV-Related Protein Encoded by a Gene on Human Chromosome 2”, Human Molecular Genetics, vol. 3, No. 7, Jul. 1993, pp. 1037-1039.
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