Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2005-01-18
2005-01-18
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C536S023200, C536S024500, C435S219000, C435S325000, C435S320100, C435S252300, C435S348000
Reexamination Certificate
active
06844180
ABSTRACT:
Novel proteins or polypeptides having significant sequence homology to DPPIV, nucleic acids coding therefor, cells which have been modified with such nucleic acid so as to express these proteins, antibodies to these proteins, screening methods for the discovery of new therapeutic agents which are inhibitors of the activity of these proteins or of related proteins, and therapeutic agents discovered by such screening methods, as well as new therapeutic treatments, are all provided.
REFERENCES:
patent: 6201132 (2001-03-01), Jenkins et al.
patent: 6291662 (2001-09-01), Bandyopadhyay et al.
patent: WO 00 42201 (2000-07-01), None
patent: WO 00 58473 (2000-10-01), None
patent: WO 0119866 (2001-03-01), None
patent: WO 01 55399 (2001-08-01), None
Abbott et al., Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homology, DPP8,Eur. J. Biochem. 267, 6140-6150 (2000).
Nagase T et al.: “Prediction of the Coding Sequences of Unidentified Human Genes.”DNA Research, Universal Academy Press, JP, vol. 7, No. 2, Apr. 28, 2000.
Swallprot ‘Online!’ Oct. 1, 2000, EBI Database accession No. Q9P236 (2 pages).
Yokotani N et. al.: “Non-Conservation of a Catalytic Residue in a Dipeptidyl Aminopeptidase IV-Related Protein Encoded by a Gene on Human Chromosome 2”Human Molecular Genetics, vol. 2, No. 7, Jul. 1993, pp. 1037-1039.
Swallprot ‘Online!’ Nov. 1, 1995, retrieved from EBI Database accession No. P42658 (2 pages).
Akinsanya Karen O.
Junien Jean-Louis
Oi Steve
Riviere Pierre J-M
Ferring BV
Fitch Even Tabin & Flannery
Prouty Rebecca E.
Walicka Malgorzata A.
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