Serine protease from cytotoxic killer cells

Details Serine protease from cytotoxic killer cells Serine protease from cytotoxic killer cells

1992-07-20

1993-05-25

Naff, David M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435212, 424 946, C12N 976, C12N 948, A61K 37547

Patent

active

052139778

ABSTRACT:
A human serine protease expressed in cytotoxic killer cells, having a mass of about 25.8kD, and having the amino acid residues of the serine protease charge-relay catalytic mechanism conserved is provided. The protease can be produced by recombinant DNA technology. The cDNA is also provided.

REFERENCES:
patent: 4783410 (1988-11-01), Pasternack et al.
patent: 4973555 (1990-11-01), Weisman et al.
Lobe et al. (1986) Science, 232, 858-861.
Gershenfeld et al. (1986) Science, 232, 854-858.
Aoki, et al. (1982) J. Clin. Invest., 69, 1223-1230.
Goldfarb et al. (1984) J. Exp. Med., 159, 935-951.
Pesce et al. (1967) J. Biol. Chem., 242(9), 2151-2167.
Pasternack et al. (1983) J. Immunol., 131(5), 2477-2483.
Pasternack et al. (1985) Nature, 314, 743-745.

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