Serine protease derived-polypeptides and anti-peptide antibodies

Details Serine protease derived-polypeptides and anti-peptide antibodies Serine protease derived-polypeptides and anti-peptide antibodies

1994-08-22

1997-10-21

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 530326, 530328, A61K 3800, C07K 706, C07K 708

Patent

active

056796390

ABSTRACT:
The present invention describes polypeptides and anti-peptide antibodies capable of inhibiting serine protease enzymatic activity. In particular, polypeptides and anti-peptide antibodies derived from the blood coagulation serine proteases Factor VIIa, Factor IXa, Factor Xa, Factor XIa, thrombin and plasma kallikrein are described that are capable of inhibiting coagulation. The polypeptide and antibody are useful in methods and systems for inhibiting serine proteases, and particularly for inhibiting blood coagulation processes mediated by serine proteases in vitro or in a human patient.

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