Serine protease BSSP2

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

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C435S004000, C435S023000, C435S024000, C435S069100, C435S183000, C536S023200, C536S063000, C536S023600, C536S023700, C536S023740

Reexamination Certificate

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06908756

ABSTRACT:
There are provided proteins having the amino acid sequences represented by SEQ ID NOS: 2, 4, 6, 8 and 10; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and nucleotide sequences encoding the same; transgenic non-human animals with altered expression level of a serine protease BSSP2; an antibody against BSSP2; and a method for detecting BSSP2 in a specimen by using the antibody.

REFERENCES:
patent: 2004/0048294 (2004-03-01), Ruben et al.
patent: 0 949 334 (1999-10-01), None
Kishi et al. NCBI Accession 1NPM B-1998.
Leytus et al. A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells.Biochemistry. Feb. 9, 1988;27(3):1067-74.
NCBI Accession S00845.
Yamashiro et al., “Molecular cloning of a novel trysin-like serine protease (neurosin) preferentially expressed in brain”,Biochimica et Biophysica Acta, (1997), pp. 11-14.
DATABASE EMBL, Jun. 7, 1999, 2 pages.
DATABASE EMBL, Oct. 13, 1997, 2 pages.
Little, S.P. et al. “Zyme, a novel and potentially amyloidogenitc enzyme CDNA isolated from Alzheimer's disease brain”, The Journal of Biological Chemistry (1997) vol. 272, No. 40 pp. 25135-25142.
Yamaura, Y. et al. “Molecular cloning of a novel brain specific serine protease with a kringle-like structure and three scavenger receptor cysteine-rich motifs”, Biochemical and Biophysical Research Communications (1997) vol. 239, No. 2 pp. 386-392.
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Hinds, T.R. et al., “Relationship between serum α1-antichymotrypsin and Alzheimer's disease”, Neurobiology of Aging (1994). vol. 15, No. 1p. 21-27.

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