Serine protease and uses thereof

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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4352402, 4352523, 4353201, 536 232, C12Q 168, C12N 510, C12N 1574, C07H 2102

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active

055003443

ABSTRACT:
The present invention provides a purified and isolated nucleic acid molecule encoding serine protease (Met-ase) having Met-ase activity but not Asp-ase activity and a molecular weight of about 30,000 daltons on SDS PAGE under reducing and non-reducing conditions. The present invention also provides a vector comprising this nucleic acid molecule, a prokaryotic or eukaryotic host cell stably transformed or transfected with the vector, as well as a method for detecting this nucleic acid in a sample.

REFERENCES:
Davis et al Basic Methods in Molecular Biology, Elsevier, N.Y., 1986, 338 pages. ("Contents", pp. V-VIII).
Natural Immunity Abstracts, "Purification and Cloning of a Novel Serine Protease with MET-Ase Activity from the Granules of a Rat Natural Killer Cell Line", p. 139, Sep.-Oct. 1992.
The FASEB Journal Abstracts, "Purification and Characterization of the Lymphocyte Serine Protease MET-Ase-1," No. 6201, vol. 6, No. 5, Feb. 28, 1992.
Current Opinion in Biotechnology, 1991, 2:76-85; "Gene Probes," James C. Richards.
The Journal of Biological Chemistry, vol. 267, No. 34, Dec. 5, 1992, pp. 24418-24425, Smyth et al. "Purification and Cloning of a Novel Serine Protease, RNK-Met-1, from the Granules of a Rat Natural Killer Cell Leukemia."
The Journal of Immunology, vol. 151, No. 11, Dec. 11, 1993, pp. 6195-6205, Smyth et al., "Met-ase: Cloning and Distinct Chromosonal Location of a Serine Protease Preferentially Expressed in Human Natural Killer Cells".
Odake, S., et al. Biochemistry 30:2217-2227 (1991).
Poe, M., et al. J. Biol. Chem. 266:98-103 (1991).
Hudig, D., et al. J. Immunology 147:1360-1368 (1991).
Fruth, U., et al. Eur. J. Immunology 17:1625-1633 (1987).
Poe, M., et al. J. Biol. Chem. 263(26):13215-13222 (1988).
Gershenfield, H. K., et al. Proc. Natl. Acad. Sci. USA 85:1184-1188 (1988).
Hameed, A., et al. J. Immunology 141:3142-3147 (1988).
Young, J. D.-E., et al. Cell 47:183-194 (1986).
Schmid, J. and Weissmann, C. J. Immunology 139:250-256 (1987).
Gershenfield, H. K. and Weissman, I. L. Science 232:854-858 (1986).
Lobe, C. G., et al. Science 232:858-861 (1986).
Brunet, J.-F., et al. Nature 322:268-271 (1986).
Sayers, T. J., et al. J. Immunology 148:292-300 (1992).
Zunino, S. J., et al. J. Immunology 144:2001-2009 (1990).
Shi, L., et al. J. Exp. Med. 175:553-566 (1992).
Zunino, S. J., et al. Biochimica et. Biophysica Acta 967:331-340 (1988).
Millard, P. J., et al. J. Immunology 132(6):3197-3204 (1984).
Nelson, R. B. and Siman, R. J. Bio. Chem. 265(7):3836-3843 (1990).
Tschopp, J. and Jonganeel, C. V. Prosp. Bioch. 27(8):2641-2646 (1988).
Ojcius, D. M., et al. Proc. Natl. Acad. Sci. USA 88:4621-4625 (1991).
Pasternack, M. S. and Eisen, H. N. Nature 314:743-745 (1985).
Lobe, C. G., et al. Proc. Natl. Acad. Sci. USA 83:1448-1452 (1986).
Jiang, S., et al. Protein Exp. and Purif. 1:77-80 (1990).
Lin, C.,-C., et al. Cell 51:393-403 (1987).
Jenne, D. E., et al. Biochemistry 28:7953-7961 (1989).
Kwon, B. S., et al. J. Exp. Med. 168:1839-1854 (1988).
Manyak, C. L., et al. J. Immunology 142:3707-3713 (1989).
Garcia-Sanz, J. A. et al. J. Immunology 145:3111-3118 (1990).
Jenne, D. E. and Tschopp, J. Immuno. Rev. 103:53-71 (1988).

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