Serine hydroxymethyltransferase as a target for herbicides

Details Serine hydroxymethyltransferase as a target for herbicides Serine hydroxymethyltransferase as a target for herbicides

2008-01-15

2008-01-15

Slobodyansky, Elizabeth (Department: 1652)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

C435S193000, C435S410000, C536S023200

Reexamination Certificate

active

07319013

ABSTRACT:
The present invention relates to serine hydroxymethyltransferase (E.C. 2.1.2.1) as novel target for herbicides, and to nucleic acid sequences encoding a polypeptide with the biological activity of a serine hydroxymethyltransferase, which, when not present, bring about growth retardation symptoms and chlorotic leaves, comprising the nucleic acid sequence SEQ ID No:3, and functional equivalents of the abovementioned nucleic acid sequence or the nucleic acid sequence SEQ ID NO:7 and functional equivalents of the abovementioned nucleic acid sequence. Moreover, the present invention relates to the use of the abovementioned nucleic acid sequences, of functional analogs of the SEQ ID NO:3 or SEQ ID NO:7 or of polypeptides encoded by one of the abovementioned nucleic acid sequences in a method for identifying herbicidally active compounds which inhibit serine hydroxymethyltransferases, and to the use of these compounds which have been identified by the method as herbicides.

REFERENCES:
patent: 5187071 (1993-02-01), Fischer et al.
patent: 6436657 (2002-08-01), Famodu et al.
patent: 1 033 405 (2000-09-01), None
patent: WO 98/33925 (1998-08-01), None
patent: WO 00/04163 (2000-01-01), None
patent: WO 00/77185 (2000-12-01), None
patent: WO 01/79514 (2001-10-01), None
The Arabidopsis Genome Initiative, Nature, 2000, 408 (6814) : 796-815.
Bouche et al, Curr. Op. Plant Biol. 4, 2001, pp. 111-117.
Kopriva S., Bauwe H.; “Serine hydroxymethyltransferase fromSolanum tuberosum”, Plant Physiology, vol. 107, No. 1, 1995, p. 271-272.
Copriva S. & Bauwe H.: Clonino and sequencing of two isoforms of serine hydroxymethyltransferase fromFlaveria pringlei, Plant Phvsioloqv, vol. 116, 1998, p. 1603.
GenBank, Database, Jul. 17, 1997, Macas J. et al.: “0521-2 NEST Tobacco leaf 01Nicotiana tabacumcDNA 3, mRNA sequence”, Database accession No. AA523562.
Martin F P-D et al.: “A hybrid-potential free-energy study of the isomerization Step of the acetohydroxy acid isomeroreductase reaction”, Journal of the American chemical society, Aug. 16, 2000, vol. 122, No. 32, p. 7688-7697.
Hanson Andrew D. et al.: “Plant one-carbon metabolism and its engineering”, Trends in Plant Science, vol. 5, No. 5, (May 2000), p. 206-213.
Douce Roland et al.: “The glycine decarboxylase system”: A fascinating complex, Trends in Plant Science, vol. 6, No. 4, (Apr. 2001), p. 167-176.
P. J. Lea et al.: “The use of mutants and transgenic plants to study amino acid metabolism”, Plant Cell and environment, vol. 17, No. 5,1994,p. 541-556.
Ashworth D J et al.: “Direct observation of Glycine metabolism in Tobacco Nicotiana-Tabacum suspension cells by carbon-13, NMR SPECTROSCOPY”, Biochemistry, vol. 23, No. 10, 1984,p. 2252-2257.
Peterson R B: “Regulation of Glycine Decarboxylase and L Serine Hydroxymethyl Transferase Activities by Glyoxylate in Tobacco NicotianaTabacum Cultivar, John-Williams-Broadleaf Leaf Mitochondrial, Preparations”, Plant Physiology (Bethesda), vol. 70, No. 1, 1982,p. 61-66.
Database GENSEQ, Alexandrov N. et al.: “Arabidopsis thalianaprotein fragment” SEQ ID No. 54248, XP002250359, Database accession No. AAG43405, Oct. 18, 2000.
Database GENSEQ, Alexandrov N. et al.: “Arabidopsis thalianaprotein fragment”SEQ ID No. 54249, XP 002250360, Database accession No. AAG43406, Oct. 18, 2000.
Database GENSEQ, Alexandrov N. et al.: “Arabidopsis thalianaprotein fragment”SEQ ID No. 54250, XP 002250361, Database accession No. AAG43407, Oct. 18, 2000.
Database GENSEQ, Alexandrov N. et al.: Zea mays protein fragment SEQ ID No. 41407, XP 002250362 Database accession No. AAG34075, Oct. 18, 2000.
Database GENSEQ, Alexandrov N. et al.: Zea mays protein fragment SEQ ID No. 41406, XP 002250363Database accession No. AAG34074, Oct. 18, 2000.
Database GENSEQ, Alexandrov N. et al.: Zea mays protein fragment SEQ ID No. 41408, XP 002250364Database accession No. AAG34076, Oct. 18, 2000.
Database EMBL, Turner S. R. et al.: Pisum sativum serine hydroxymethyltransferase mRNA, complete cds, Database accession No. M87649, Aug. 29, 1992.
Database EMBL, Bauwe H.: “Flaveria pringleimRNA for glicine hydroxymethyltransferase”, database accession No. 225860.
Database EMBL, Database, Nov. 20, 2001, Wang H. & Bohnert H.: ,Zea mays serine hydroxymethyltransferase mRNA, partial cds, Database accession No. AF439728.

Affiliated with

Also associated with

Rating

Serine hydroxymethyltransferase as a target for herbicides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Serine hydroxymethyltransferase as a target for herbicides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Serine hydroxymethyltransferase as a target for herbicides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2758138