Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Patent
1997-10-28
2000-12-05
Celsa, Bennett
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
435 71, 436 8, 436518, 530333, 536 253, 536 2531, C12Q 100, G01N 3100, C07K 104, C07B 6100
Patent
active
06156494&
ABSTRACT:
A method has been developed which utilizes functionalized optical fibers as a solid support for the assembly of combinatorial libraries of compounds. The optical fibers are used to direct light, heat or a combination thereof to the compounds tethered to the fibers surface. Utilizing the method of the instant invention reactions occurring by both photochemically and thermally allowed pathways are accessible. In a preferred embodiment of the invention, the optical fibers are used to screen the array by fluorescence spectroscopy of labeled target molecules which bind to the immobilized library compounds.
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Hensman,et al., "Total radiated power, infrared output, and heat generation by cold light sources at the distal end of endoscopes and fiber optic bundle of light cables," Surg. Endosc., 12:335-337 (1998).
Adams Christopher
Boles T. Christian
Sridhar Coimbatore Nagaraja
Celsa Bennett
Mosaic Technologies
Ricigliano Joseph W.
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