Serial derivatization of peptides for de novo sequencing...

Details Serial derivatization of peptides for de novo sequencing... Serial derivatization of peptides for de novo sequencing...

2008-05-13

2008-05-13

Gitomer, Ralph (Department: 1657)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Reexamination Certificate

active

10892870

ABSTRACT:
Serial derivatization by chemical reactions of analytes for mass spectrometry is disclosed. The derivatizations enhance the use of MS techniques for analyzing protein samples, particularly when the sequence of a polypeptide is determined by tandem MS/MS. Accurate mass analysis techniques are described for use in sequencing polypeptides, together with the use of sequencing data in protein analysis.

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