Sequestered imaging agents

Details Sequestered imaging agents Sequestered imaging agents

1995-05-31

1998-09-08

Kight, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 111, 424 165, 530300, 530328, 530329, 530330, 534 14, A61K 5100, A61M 3614

Patent

active

058041583

ABSTRACT:
Compounds useful for high resolution diagnostic imaging incorporate an imaging agent having a chelator that is linked by a metal-cleavable bond to a ligand that has affinity for a site removed from the site of diagnostic interest. Upon labelling, the ligand is cleaved leaving the labelled imaging agent free to localize at the site of diagnostic interest unhindered, while the ligand and any unlabelled imaging agent is sequestered to the removed site. By sequestering unlabelled imaging agent, the labelled imaging agent does not compete to occupy the site of interest, resulting in images of enhanced resolution.

REFERENCES:
patent: 4421735 (1983-12-01), Haber et al.
patent: 4678667 (1987-07-01), Meavrs et al.
patent: 4946668 (1990-08-01), Daddona et al.
patent: 4980147 (1990-12-01), Fritzberg et al.
patent: 5171563 (1992-12-01), Abrams et al.
patent: 5242679 (1993-09-01), Fritzberg et al.
patent: 5480970 (1996-01-01), Pollak et al.
patent: 5556982 (1996-09-01), Fritzberg et al.
patent: 5569745 (1996-10-01), Goodbody et al.
patent: 5662885 (1997-09-01), Pollak et al.

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