Sequential heat treatment of blood-clotting factor products

Details Sequential heat treatment of blood-clotting factor products Sequential heat treatment of blood-clotting factor products

1990-06-06

1992-06-02

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530380, C07K 1300, A61K 3700

Patent

active

051187957

ABSTRACT:
It is found that blood clotting-factor products previously subjected to monoclonal purification or solvent-detergent treatment or both may be further subjected to a sequence of heating steps without excessive loss of usable product to reduce the infectivity of a virus (such as hepatitis- or AIDS-causing virus), if present. The heating is performed while the concentrate is lyophilized (freeze dried). The heating steps in the sequence are for two or more different times, and at two or more different temperatures. After the heating sequence, the concentrate is reconstituted for use. This sequential method contemplates greater inactivation of different viral forms, or reduction of the heating required, or both. Reduction of heating requirements may appear as reduced overall heating time, or reduced aggregate power consumption, or both. Advantages include heightened quality-control assurance level.

REFERENCES:
patent: 4456590 (1984-06-01), Rubinstein
patent: 4556558 (1985-12-01), Rubinstein

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