Sequential C-terminal degradation of peptides and proteins using

Details Sequential C-terminal degradation of peptides and proteins using Sequential C-terminal degradation of peptides and proteins using

1990-08-13

1991-10-22

Hill, Jr., Robert J.

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

Amino acid or sequencing procedure

530345, 530402, 530408, 530815, G01N 3368

Patent

active

050595407

ABSTRACT:
Reagents useful for the C-terminal sequencing of proteins and peptides are disclosed. The reagents include sodium trimethylsilanolate and trimethyl N-oxide. The reagents are used as cleaving reagents in a method for the sequential C-terminal degradation of peptides and proteins.

REFERENCES:
patent: 4837165 (1989-06-01), Hawke
patent: 4935494 (1990-06-01), Miller

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