Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...
Patent
1994-03-01
1996-11-05
Niebling, John
Chemistry: electrical and wave energy
Processes and products
Electrophoresis or electro-osmosis processes and electrolyte...
204466, 204612, 204616, 435 6, 435968, 436800, G01N 2726, G01N 27447, C12Q 168
Patent
active
055713882
ABSTRACT:
To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.
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Strekowski, L., et al., 1992, "Substitution Reactions of a Nucleofugal Group in Heptamethine Cyanine Dyes. Synthesis of an Isothiocyanato Derivative for Labeling of Proteins with a Near-Infrared Chomophore", J. Organ. Chem., 57:4578-4580.
Lipowska, M., et al., 1993, "New Near-Infrared Cyanine Dyes for Labeling of Proteins", Synthetic Communications, 23(21):3087-3094.
Lipowska Malgorzata
Middendorf Lyle R.
Narayanan Narasimhachari
Patonay Gabor
Strekowski Lucjan
Carney Vincent L.
Li-Cor Inc.
Niebling John
Starsiak Jr. John S.
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