Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-03-20
2007-03-20
McGarry, Sean (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C514S04400A, C435S320100
Reexamination Certificate
active
10005337
ABSTRACT:
The invention relates to novel promoter sequences derived from a portion upstream of the coding sequence of the gene for the CARP protein (Cardiac Ankyrin Repeat Protein), and which are capable of controlling the level and the specificity of expression of a transgene in vivo in cardiac muscle cells. The invention thus describes novel compositions, constructs, vectors and their uses in vivo for the transfer and expression of a nucleic acid in vivo in cardiac muscle cells. The subject of the present invention is also the use of the promoter sequences for generating transgenic animals which constitute models for studying certain cardiac pathologies.
REFERENCES:
patent: WO 00/15821 (1999-09-01), None
patent: WO 00/15821 (2000-03-01), None
Aihara et al., “Homo sapiensCardiovascular-specific Cardiac Ankyrin Repeat Protein (CVARP) Gene. 5′-Flanking Region and Exon 1,” EMBL Database Accession No. AF131884, Feb. 15, 2000.
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Alarco et al. The bZip Transcription factor Cap1p is involved in multidrug resistance and oxidative stress response inCandida albicans. Journal of Bacteriology, 1999 vol. 181:700-708.
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Phillip et al. Gene Modification of Primary tumor cells for active immunotherapy of human breast and ovarian cancer. Clinical Cancer Research, 1996 vol. 2:59-68.
Chen et al. Overexpression of human endothelial nitric oxide synthase in rat vascular smooth muscle cells and in balloon-injured carotid artery. Circulation Reseach, 1998 vol. 82:862-70.
Aihara et al. “Homo sapiensCardiovascular-Specific Cardiac Ankyrin Repeat Protein (CVARP) Gene, 5′Flanking Region and Exon 1,” EMBL Database Accession No. AF131884, Feb. 15, 2000. See sequence alignment.
Fu et al. Viral sequences enable efficient and tissue-specific expression of transgenes in Xenopus. Nature Biotechnology, 199 vol. 16:253-257.
Hai-Chien et al., “Control of Segmental Expression of the Cardiac-Restricted Ankyrin Repeat Protein Gene by Distinct Regulatory Pathways in Murine Cardiogenesis,”Development, vol. 126, pp. 4223-4234, 1999.
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Zou et al., “CARP, a Cardiac Ankyrin Repeat Protein, is Downstream in the Nkx2-5 Homeobox Gene Pathway,”Development, vol. 124, 793-804, 1997.
Benoit Patrick
Branellec Didier
Chen Ju
Chien Kenneth R.
Schwartz Bertrand
Centelion
Finnegan Henderson Farabow Garrett & Dunner LLP
Gibbs Terra C.
McGarry Sean
The Regents of the University of California
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