Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-03-17
2010-02-16
Myers, Carla (Department: 1634)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023500, C435S069100, C435S183000, C435S325000, C435S252300, C435S320100
Reexamination Certificate
active
07662946
ABSTRACT:
The present invention relates to a disintegrin and metalloproteinase containing thrombospondin 1-like domains (ADAMTS) and in particular to a novel ADAMTS13 protease and to nucleic acids encoding ADAMTS13 proteases. The present invention encompasses both native and recombinant wild-type forms of ADAMTS13, as well as mutant and variant forms including fragments, some of which posses altered characteristics relative to the wild-type ADAMTS13. The present invention also relates to methods of using ADAMTS13, including for treatment of TTP. The present invention also relates to methods for screening for the presence of TTP. The present invention further relates to methods for developing anticoagulant drugs based upon ADAMTS13.
REFERENCES:
patent: 5830731 (1998-11-01), Seed et al.
patent: 6310183 (2001-10-01), Johannessen et al.
patent: 6926894 (2005-08-01), Laemmle et al.
patent: 7112666 (2006-09-01), Soejima et al.
patent: 2001/0049106 (2001-12-01), Buckbinder et al.
patent: 2003/0105313 (2003-06-01), Racie et al.
patent: 2005/0101529 (2005-05-01), Yue et al.
Skolnick et al. Trends in Biotechnology. 2000. 18(1): 34-39.
Verma et al. Nature, 1997, vol. 389, pp. 239-242.
Orkin et al.“Report and Recommendation of the Panel to Assess the NIH Investment in Research on Gene Therapy”, NIH, 1995.
Thomas et al. Nature. 2003. 4: 346-358.
Blobel, C.P., “Metalloprotease-disintegrins: links to cell adhesion and cleavage of TNFα and Notch,” Cell, vol. 90, Aug. 22, 1997, pp. 589-592.
Colige, A., et al., “Human Ehlers-Danlos Syndrome Type VII C and Bovine Dermatosparaxis are Caused by Mutations in the Procollagen I N-Proteinase Gene,” Am. J. Hum. Genet. 65:308-317, 1999.
Dent, Judith A. et al., “Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor,” Proc. Natl. Acad. Sci, USA, vol. 87, Aug. 1990, pp. 6306-6310.
Fujikawa et al., “Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family,”. Blood. Sep. 15, 2001, vol. 98, No. 6, pp. 1665-1666.
Furlan, Miha, et al., “Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis,” Blood, vol. 87, No. 10, May 15, 1996, pp. 4223-4234.
Furlan, Miha, et al., “von Willebrand factor—cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome,” The New England Journal of Medicine, vol. 339, No. 22, Nov. 26, 1998, pp. 1578-1584.
George, James N., “How I treat patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome,” Blood, Aug. 15, 2000, pp. 1223-1229.
Kaushal, G.P. & Shah, S.V., “The new kids on the block: ADAMTs, potentially multifunctional metalloproteinases of the ADAM family,” the Journal of Clinical Investigation, vol. 105, No. 10, May 2000, pp. 1335-1337.
Kokame, Koichi, et al., “Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity,” PNAS, Sep. 3, 2002, vol. 99, No. 18, pp. 11902-11907.
Kuno, K., et al. “Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene,” The Journal of Biological Chemistry, vol. 272, No. 1, Jan. 3, 1997, pp. 556-562.
Levy et al., “Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura.” Nature. Oct. 4, 2001, vol. 413, pp. 488-494.
Mannucci, et al., “Enhanced proteolysis of plasma von Willebrand factor in thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome,” Blood, vol. 74, No. 3, Aug. 15, 1989, pp. 978-983.
Matsumoto, Masanori, et al., “Molecular characterization of ADAMTS13 gene mutations in Japanese patients with Upshaw-Schulman syndrome,” Blood, Feb. 15, 2004, vol. 103, No. 4, pp. 1305-1310.
Mitra, Debashis, et al., “Thrombotic thrombocytopenic purpura and sporadic hemolytic-uremic syndrome plasmas induce apoptosis in restricted lineages of human microvascular endothelial cells,” Blood, vol. 89, No. 4, Feb. 15, 1997, pp. 1224-1234.
Moake, Joel L., et al., “Unusually large plasma factor VIII: von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura,” The New England Journal of Medicine, Dec. 2, 1982, pp. 1432-1435.
Peyvandi, Flora, et al., “von Willebrand factor cleaving protease (ADAMTS-13) and ADAMTS-13 neutralizing autoantibodies in 100 patients with thrombotic thrombocytopenic purpura,” British Journal of Haematology, vol. 127, 2004, pp. 433-439.
Pharmacia Biotech, Inc., Molecular and Cell Biology Catalog, 1993, pp. 120-123.
Pimanda, John E., et al., “Congenital thrombotic thrombocytopenic purpura in association with a mutation in the second CUB domain of ADAMTS13,” Blood, Jan. 15, 2004, vol. 103, No. 2, pp. 627-629.
Rock, Gail A., et al., “Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura,” The New England Journal of Medicine, Aug. 8, 1991, pp. 393-397.
Tang G.L., “ADAMTS: a novel family of extracellular matrix proteases,” The International Journal of Biochemistry & Cell Biology, vol. 33, No. 1, Jan. 2001, ISSN 1357-2725, pp. 33-44.
Tortorella, M.D., et al.,“Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins,” Science, vol. 284, Jun. 4, 1999, pp. 1664-1666.
Tsai, Han-Mou et al., “Proteolytic cleavage of recombinant Type 2A von Willebrand factor mutants R834W and R834Q: Inhibition by Coxycycline and by Monoclonal Antibody VP-1,” Blood, vol. 89, No. 6, Mar. 15, 1997, pp. 1954-1962.
Tsai, Han-Mou, “Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion,” Blood, vol. 87, No. 10, May 15, 1996, pp. 4235-4244.
Tsai, Han-Mou, et al., “Antibody Inhibitors to von Willebrand Factor Metalloproteinase and Increased Binding of von Willebrand Factor to Platelets in Ticlopidine-Associated Thrombotic thrombocytopenic Purpura,” Annals of Internal Medicine, vol. 132, No. 10, pp. 794-799, May 2000.
Uchida, Toshihiro, et al., “Identification of novel mutations in ADAMTS13 in an adult-patient withi congenital thrombotic thrombocytopenic purpura,” Blood, Oct. 1, 2004, vol. 104, No. 7, pp. 2081-2083.
Ginsburg David
Levy Gallia
Tsai Han-Mou
Casimir Jones S.C.
Myers Carla
The Regents of the University of Michigan
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