Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification
Patent
1997-06-27
1999-10-26
Sisson, Bradley L.
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
435 911, 435445, 514 44, 536 231, C07H 2102, C12P 1934, A01N 4304
Patent
active
059727055
ABSTRACT:
The invention features nucleic acid molecules and methods for use in site-specific methylation of ribonucleotides. The methods of the invention can be used to modulate RNA folding, RNA processing, RNA cleavage, and other processes involving sequence-specific recognition of RNA sequences, as well as for promoting RNA stability.
REFERENCES:
Bachellerie et al., "Antisense snoRNAs: a family of nucleolar RNAs with long complementarities to rRNA", Elsevier Trends Journals 20:261-264, 1995.
Caffarelli, et al., "Processing of the Intro-Encoded U16 and U18 snoRNAs: The Conserved C and D Boxes Conrol Both the Processing . . . of the Mature snoRNA", The EMBO Journal, 15(5):1121-1131, 1996.
Cavaille et al., "Targeted ribose methylation of RNA in vivo directed by tailored antisense RNA guides", Nature 383:732-735, 1996.
Eichler et al., "Isolation and Characterization of a Nucleolar 2'-0-Methyltransferase from Ehrlich Ascites Tumor cells", Biochemistry 26:1639-1644, 1987.
Kiss-Laszlo, et al., "Site-Specific Sugar Methylation of rRNA: A novel function for small nuclear RNAs", Abstract RNA '96, The First Annual Meeting of the RNA Society, May 28 to Jun. 2, 1996, Madison, Wisconsin.
Kiss-Laszloo, et al., "Site-Specific Ribose Methylation of Preribosomal RNA: A Novel Function for Small Nucleolar RNAs", Cell 85:1077-1088, 1996.
Nicoloso et al., "Intron-encoded Antisense Small Nucleolar RNAs: The Characterization of Nine Novel Species Points to Their Direct Role as Guides for the 2'-0-ribose Methylation of rRNAs", J. Mol. Biol 260, 178-195, 1996.
Maxwell et al., "The Small Nucleolar RNAs", Ann. Rev. Biochem 35:897-934, 1995.
Segal et al., "A Nucleolar 2'-0-Methyltransferasse", The Journal of Biological Chemistry 266(36): 24385-24389, 1991.
Tycowski et al., "A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus", Proc. Natl. Acad. Sci. USA 93:14480-14485, 1996.
Yu et al., "A new method for detecting sites of 2'0-methylation in RNA molecules", RNA 3:324-331, 1997.
Fournier Maurille J.
Ni Jingwei
Sisson Bradley L.
Stole Einar
University of Massachusetts
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