Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1992-03-31
1994-11-08
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
4353201, 536 241, 536 2431, 424 2, C12Q 168
Patent
active
053626230
ABSTRACT:
Specific sequences in the human genome are the sites of strong binding of wild-type p53 protein, but not mutant forms of the protein. These sequences are used diagnostically to detect cells in which the amount of wild-type p53 is diminished. The sequences can also be used to screen for agents which correct for loss of wild-type p53 to DNA in cancer cells.
REFERENCES:
Eliyahu et al, Proc. Natl. Acad. Sci. U.S.A., vol. 86, pp. 8763-8767, Nov. 1989.
Kern, et al., "Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression", Science, 256:827-830(1992).
El-Deiry, et al., "Definition of a Consensus Binding Site for p53", Nature Genetics, 1:45-49 (1992).
Bargonazzi, et al., "Wild-Type But Not Mutant p53 Immunopurified Protein Bind to Sequences Adjacent to the XV40 Origin of Replication", Cell, 65:1-9 (1991).
Jelinek, et al., "Ubiquitous, Interspersed Repeated Sequences in Mammalian Genomes", Proc. Natl. Acad. Sci. USA, 77(3):1398-1402(1980).
Mercer, et al., "Negative Growth Regulation in a Glioblastoma Tumor Cell Line that Conditionally Expresses Human Wild-Type p53", Proc. Natl. Acad. Sci. USA, 87:6166-6170(1990).
Diller, et al., "p53 Functions as a Cell Cycle Control Protein in Osteosarcomas", Molecular and Cellular Biology, 10(11):5772-5781 (1990).
Baker, et al., "Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53", Science, 249:912-915 (1990).
Kern, et al., "Mutant p53 Proteins Bind DNA Abnormally in vitro", Oncogene, 6(1):131-136 (1990).
Kinzler Kenneth W.
Sherman Michael I.
Vogelstein Bert
Nucker Christine M.
PharmaGenics, Inc.
Scheiner Laurie
The John Hopkins University
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