Sequence-specific binding polymers for duplex nucleic acids

Details Sequence-specific binding polymers for duplex nucleic acids Sequence-specific binding polymers for duplex nucleic acids

1991-06-20

1992-11-24

Foelak, Morton

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From heterocyclic reactant containing as ring atoms oxygen,...

528403, 528425, 528422, 528423, C08G 5900, C08G 6500

Patent

active

051663155

ABSTRACT:
A polymer composition effective to bind in a sequence-specific manner to a target sequence of a duplex polynucleotide containing different Watson-Crick basepair oreientaions. The composition includes an uncharged backbone with 5- or 6-membered cyclic backbone structures and selected bases attached to the backbone structures effective to hydrogen bond specifically with different oriented basepairs in the target sequence.

REFERENCES:
patent: 4558047 (1985-12-01), Takaya et al.
Buneman, H. et al., Biochem. 20:2864-2874 (1981).
Chamberlin, M. J. and Patterson, D. L., J. Mol. Biol. 12:410-428 (1965).
Cooney, M. et al., Science 241:456-459 (1988).
Fischer-Fantuzzi, L. and Vesco, C., Mol. & Cell. Biol. 8(12):5495-5503 (1988).
Gregoriadis, G. and Neerunjun, E. D., Biochem. & Biophys. Res. Communications 65(2):537-544 (1975).
Hoogsteen, K., Acta Cryst. 12:822 (1959).
Inman, R. B., J. Mol. Biol. 10:137-146 (1964).
Kosturko, L. D. et al., Biochem. 18(26):5751-5756 (1979).
Kundu, N. and Heidelberger, C., Biochem. & Biophys. Res. Comm. 60(2):561-568 (1974).
Kundu, N. G. et al., J. Med. Chem. 18(4):395-399 (1975).
Kundu, N. G. et al., J. Med. Chem. 18(4):399-403 (1975).
Kundu, N. G., J. Med. Chem. 23:512-516 (1980).
Maher III, L. J. et al., Science 245:725-730 (1989).
Morgan, A. R. and Wells, R. D., J. Mol. Biol. 37:63-80 (1968).
Moser, H. E. and Dervan, P. B., Science 238:645-650 (1987).
Pelaprat, D. et al., J. Med. Chem. 23:1330-1335 (1980).
Pelaprat, D. et al., J. Med. Chem. 23:1333-1343 (1980).
Povsic, T. J. and Dervan, P. B., J. Am. Chem. Soc. 111:3059-3061 (1989).
Schultz, P. G. et al., J. Am. Chem. Soc. 104(24):6861-6863 (1982).
Schultz, P. G. and Dervan, P. B., Proc. Natl. Acad. Sci. USA 80:6834-6837 (1983).
Sluka, J. P. et al., Science 238:1129-1132 (1987).
Youngquist, R. S. and Dervan, P. B., J. Am. Chem. Soc. 107:5528-5529 (1985).
Zuidema, D. et al., Nucleic Acids Res. 5(7):2471-2483 (1978).

Affiliated with

Also associated with

Rating

Sequence-specific binding polymers for duplex nucleic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sequence-specific binding polymers for duplex nucleic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sequence-specific binding polymers for duplex nucleic acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-922684