Sequence pattern descriptors for transmembrane structural...

Details Sequence pattern descriptors for transmembrane structural... Sequence pattern descriptors for transmembrane structural...

2011-08-02

2011-08-02

DeJong, Eric S (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Biological or biochemical

C702S022000, C703S011000

Reexamination Certificate

active

07991563

ABSTRACT:
The relationship between an amino acid sequence of a protein and its three-dimensional structure is at the very core of structural biology and bioinformatics. The occurrence and conservation of non-canonical conformations is a “local” phenomenon, i.e., non-canonical conformations are encoded intra-helically by short peptide sequences (heptapeptides at most). Effective descriptors can be formed for these short sequences employing training sets. Multiple, distinct patterns are created representing these sequences. A composite descriptor is formed by selecting from among the patterns discovered. The composite descriptor has a high level of sensitivity and specificity while, at the same time, a boosted signal-to-noise ratio.

REFERENCES:
patent: 5948887 (1999-09-01), Evans et al.
patent: 2002/0146724 (2002-10-01), Toll et al.
Frishman et al. “KNowledge-Based Protein Secondary Structure Assignment” Proteins:Structure, Function, Genetics (1995) vol. 23, pp. 566-579.

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