Sequence of AF1q cDNA

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 221, C07H 2102, C07H 2104

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058080260

ABSTRACT:
A novel gene, AF1q, is described and its cDNA sequence provided. Methods are provided for detection of malignancies in humans by examining the level of expression of or the integrity of the AF1q gene.

REFERENCES:
Tse et al, Blood 85(3):650-6, 1995.
Croce, C.M., "Role of Chromosome Translocations in Human Neoplasia", Cell 49:155-6, 1987.
Gauwerky, C.E. et al, "Chromosomal Translocations in Leukaemia", Semin Cancer Biol 4:333-40, 1993.
Kearney, L. et al, "Chromosome 11q23 Translocations in Both Infant and Adult Acute Leukemias Are Detected by in Situ Hybridization With a Yeast Artificial Chromosome", Blood 80:1659-65, 1992.
Petkovic, I. et al, "Cytogenetic Analysis in Children with Acute Nonlymphocytic Leukemia", Cancer Genet Cytogenet 58:155-9, 1992.
Young, B.D., "Cytogenetic and Molecular Analysis of Chromosome 11q23 Abnormalities In Leukaemia", Baillieres Clin Haematol 5:881-95, 1992.
Peu Ching-Hon, C.W.M. et al, "Biology and Clinical Significance of Cytogenetic Abnormalities in Childhood Acute Lymphoblastic Leukemia", Blood 76:1449-1463, 1990.
Heim, S.M., Cancer Cytogenetics 1987.
Djabali, M. et al, "A Trithorax-Like Gene is Interrupted by Chromosome 11q23 Translocations in Acute Leukaemias", Nat Genet 2:113-8, 1992.
Gu, Y et al, The t(4;11) "Chromosome Translocation of Human Acute Leukemias Fuses the ALL-1 Gene, Related to Drosophila Trithorax, to the AF-4 Gene", Cell 71:701-8, 1992.
Tkachuk, D.C. et al, "Involvement of a Homolog of Drosophila Trithorax by 11q23 Chromosomal Translocations in Acute Leukemias", Cell 71:691-700, 1992.
Harris, B.N. et al, "Involvement of a Homolog of Drosophila Trithorax by 11q23 Chromosomal Translocations in Acute Leukemias", Cell 71:691-700, 1992.
Harris, B.N. et al, "Variant Translocations (9;11): Identification of the Critical Genetic Rearrangement", Cancer Genet. 30:171-175, 1988.
Ma, Q. et al, "Analysis of the Murine All-1 Gene Reveals Conserved Domains with Human ALL-1 and Identifies a Motif Shared with DNA Methyltransferases", Proc. Natl Acad Sci U.S.A. 90:6350-4, 1993.
Gu, Y. et al, "E: Sequence Analysis of the Breakpoint Cluster Region in the ALL-1 Gene Involved in Acute Leukemia", Cancer Res 54:2326-30, 1994.
Hildren, J.M., "Heterogeneity in MLL/AF-4 Fusion Messenger RNA Detected by the Polymerase Chain Reaction in t(4;11) Acute Leukemia", Cancer Res 53:3853-6, 1993.
Thirman, M.J. et al, "Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q22 Chromosomal Translocation", N Engl J Med 329:909-14, 1993.
Domer P. et al, "Acute Mixed-Lineage Leukemia t(4;11) (q21;q23) Generates an MLL-AF4 Fusion Product", Proc. Natl. Acad. Sci. USA 90:7884-7888, 1993.
Bernard, O.A., et al, "A Novel Gene, AF-Ip, Fused to HRX in t(1:11) (p32;q23), is Not Related to AF-4, AF-9 nor ENL", Oncogene 9:1039-45, 1994.
Prasad, R. et al, "Leucine-Zipper Dimerization Motif Encoded by the AF17 Gene Fused to ALL-1 (MLL) in Acute Leukemia", Proc. Natl. Acad. Sci. USA 91:8107-8111, 1994.
Schichman, S.A. et al, "All-1 Partial Duplication in Acute Leukemia", Proc. natl. Acad. Sci. USA 91:6236-6239, 1994.
McCabe, N.R. et al, "Cloning of cDNAs of the MLL Gene that Detect DNA Rearrangements and Altered RNA Transcripts in Human Leukemic Cells with 11q23 Translocations", Proc. Natl. Acad. Sci. USA 89:11794-8, 1992.
Wilson, T. et al, Nature 336-396-399, 1988.
Raimondi, S.C. et al, "Childhood Acute Lymphoblastic Leukemia with Chromosomal Breakpoints at 11q23", Blood 73:1627-34, 1989.

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