Sequence analysis of the tetravalent rotavirus vaccine

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Reexamination Certificate

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C435S320100, C435S069300, C435S325000, C435S252300, C435S254110, C424S215100

Reexamination Certificate

active

07485415

ABSTRACT:
Isolated nucleic acid molecules comprising a gene segment from a rhesus rotavirus (RRV) or from one of three rhesus: human reassortant viruses are disclosed, including isolated nucleic acid molecules having a sequence selected from the group consisting of: SEQ ID NO: 1-14, inclusive, and isolated nucleic acid molecules encoding a protein having a sequence selected from the group consisting of SEQ ID NO: 15-28, inclusive, as well as variants of the isolated nucleic acid molecules.

REFERENCES:
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Dharakul T., et al., “Immunization with baculovirus-expressed recombinant rotavirus proteins VP1, VP4, VP6, and VP7 induces CD8+T lymphocytes that mediate clearance of chronic rotavirus infection in SCID mice,”J. Virol., 1:5928-5932 (Nov. 1991).
Gentsch, et al., “Review of G and P typing results from a global collection of rotavirus strains: Implications for vaccine development,”J. Infect. Dis., 174:S30-S36 (Sep. 1996).
Ito H., et al., “Complete nucleotide sequence of a group A avian rotavirus genome and a comparison with its counterparts of mammalian rotaviruses,”Virus Res., 75:123-138 (2001).
Masendycz P. and Palombo E., “Genetic relatedness of VP1 genes of Australian and Taiwanese rotavirus isolates,”FEMS Microbiol. Lett., 198:147-150 (2001).
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Nielsen P., et al., “Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide,”Science, 254:1497-1500 (Dec. 6, 1991).

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