Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...
Patent
1996-07-05
1999-07-27
Beisner, William H.
Chemistry: electrical and wave energy
Processes and products
Electrophoresis or electro-osmosis processes and electrolyte...
204456, 204466, G01N 2226, G01N 27447
Patent
active
059284846
ABSTRACT:
The invention relates to a separation procedure for Lp(a) and the various lipoproteins contained in a biological sample by electrophoresis. The present invention is characterized in that the electrophoretic migration of the lipoproteins is carried out under conditions such that the electrophoresis gel and/or the above-mentioned biological sample contains compounds capable of modifying the electrophoretic mobility of Lp(a) differentially with respect to that of the other lipoproteins.
REFERENCES:
American Journal of Human Genetics: vol. 49, No. 5, Nov. 1991, Chicago, USA, pp. 1063-1074; Kamboh M.I. et al.: `Expressed hypervariable polymorphism of apolipoprotein(a)` p. 1064, colonne de droite, ligne 22--p. 1066, colonne de gauche, ligne 19.
Electrophoresis: vol. 7, No. 5, May 1986, Weinheim, Germany pp. 197-203; Boersum T. et al.: `Electrophoretic migration velocity of amphiphilic proteins increases with decreasing Triton X-100 concentration: A new characteristic for their identification`.
Journal of Biological Chemistry: vol. 257, No. 1, Jan. 10, 1982, Baltimore US pp. 501-507; Gutermann et al.: `Genetic variants of group A apolipoproteins`.
Clinica Chimica Acta: vol. 188, No. 1, No month available 1990, Amsterdam, NL, pp. 71-77; Bruckert E. et al.: `Does electrophoresis reliably screen for high serum lipoprotein(a)?`.
Noble, R., "Electrophoretic Separation of Plasma Lipoproteins in Agarose Gel", Journal of Lipid Research, 9:693-700 (1968).
C. Desreumaux et al, "Analyse des lipoproteines par electrophorese surgel de polyacrylamide et par precipitation fractionnee a l'aide de polyanions. et de detergents." Ann. Biol. Clin. 34 No month available (1976)309-316.
Philippe Gambert et al, Cholestrol Gas-Liquid Chromatographic Micro-assay in Serum Lipoproteins Separated by Polyacrylamide Gel Electrophore Clinica Chimica Acta 100 No month available (1980) 99-105.
C. Desreumaux et al, "Fractionation of serum lipoproteins by preparative electrophoresis in polyacrylamide gel" Journal of Chromatography 130 (Jan. 1977) 336-341.
G. Utermann and W. Weber, "Protein composition of Lp(A) lipoprotein from human plasma" FEBS Letters, vol. 154, No. 2, (Apr. 1983) 357-361.
C. Desreumaux et al, "Analyse des lipoproteines par electrophorese sur gel de. polyacrylamide et par precipitation fractionee a l'aide de polyanions et de detergents" annales de Biologic Clinique No month available (1976) 309-316.
G. Utermann and W. Weber "Protein composition of Lp(A) lipoprotein from human plasma" FEBS Letters, vol. 154, No. 2 (Apr. 1983) 357-361.
S. Moulin, J.C. Fruchart, P. Dewailly, and G. Sezille, "Electrophorese Des Lipoproteines Seriques Plaque De Gel D'Acrylamide-Agarose, En Gradient Discontinu D'Acrylamide" Clinica Chimica Acta, vol. 91, No. 2 (Jan. 1979) 159-163.
Philippe Gambert, Christian Lallemant, and Prudent Padieu "Cholesterol Gas-Liquid Chromatographic Microassay In Serum Lipoproteins Separated By Polyacrylamide Gel Electrophoresis" Clinicu Chimica Acta, vol. 100/2 No month available (1980) 99-105.
Bellon Franck
Bringard Aline
Beisner William H.
Sebia
Starsiak Jr. John S.
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