Separation of the enantiomers of amlodipine via their diastereom

Details Separation of the enantiomers of amlodipine via their diastereom Separation of the enantiomers of amlodipine via their diastereom

1998-05-05

2000-04-04

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546321, C07D21380, C07D213803

Patent

active

060463384

ABSTRACT:
A method for the separation of R-(+)- and S-(-)-isomers of amlodipine (I) from mixtures thereof, which comprises the reaction of the mixture of isomers with either L- or D-tartaric acid in an organic solvent containing sufficient dimethyl sulphoxide (DMSO) for the precipitation of, respectively, a DMSO, solvate of an L-tartate salt of R-(+)-amlodipine, or a DMSO solvate of a D-tartrate salt of S-(-)-amlodipine.

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