Separation of specific biological cells by a biochemical filter

Details Separation of specific biological cells by a biochemical filter Separation of specific biological cells by a biochemical filter

1983-09-06

1987-09-08

Warden, Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

435 2, 435 30, 435261, 435311, 435803, 436824, 604 4, 604 5, C12N 100, C12N 102, A01N 102, C12Q 124

Patent

active

046924116

ABSTRACT:
Apparatus and methods for selective removal of specific biological cells or specific antigens or antibodies, from fluid containing their mixture with other biological cells and particulates are described. Filtration by this biochemical filter system is effected in a continuous closed-loop fluid flow path. The apparatus described herein comprises a source of fluid containing specific biological cells, antigens or antibodies to be removed; a source of complementary cells or complementary antibodies for the antigens and complementary antigens for the antibodies which can form large agglutinates following a biochemical reaction a reaction chamber providing conditions favorable for fast clump formation following the reaction; a filter for trapping large agglutinates; one or more pumps to regulate various flow rates; and necessary connecting links to form a closed-loop fluid flow path that includes the sources of biological cells, antigens or antibodies and complementary cells, reaction chamber, and filter chamber.

REFERENCES:
patent: 4416772 (1983-11-01), Sato et al.
patent: 4465593 (1984-08-01), Wemhoff

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